The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: A pooled analysis

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Global Burden of Metabolic Risk Factors of Chronic D Collaborating Groupiseases , Asia-Pacific Cohort Studies Collaboration (APCSC) , Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe (DECODE) , Emerging Risk Factor Collaboration (ERFC) , Prospective Studies Collaboration (PSC) , Miettinen , T , Strandberg , T & Tilvis , R 2013 , ' The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: A pooled analysis ' , PLoS One , vol. 8 , no. 7 , pp. e65174 . https://doi.org/10.1371/journal.pone.0065174

Title: The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: A pooled analysis
Author: Global Burden of Metabolic Risk Factors of Chronic D Collaborating Groupiseases; Asia-Pacific Cohort Studies Collaboration (APCSC); Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe (DECODE); Emerging Risk Factor Collaboration (ERFC); Prospective Studies Collaboration (PSC); Miettinen, Tatu; Strandberg, Timo; Tilvis, Reijo
Contributor: University of Helsinki, Department of Medicine
University of Helsinki, Clinicum
University of Helsinki, Geriatrian yksikkö
Date: 2013
Language: eng
Number of pages: 10
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/165115
Abstract: BACKGROUND: The effects of systolic blood pressure (SBP), serum total cholesterol (TC), fasting plasma glucose (FPG), and body mass index (BMI) on the risk of cardiovascular diseases (CVD) have been established in epidemiological studies, but consistent estimates of effect sizes by age and sex are not available. METHODS: We reviewed large cohort pooling projects, evaluating effects of baseline or usual exposure to metabolic risks on ischemic heart disease (IHD), hypertensive heart disease (HHD), stroke, diabetes, and, as relevant selected other CVDs, after adjusting for important confounders. We pooled all data to estimate relative risks (RRs) for each risk factor and examined effect modification by age or other factors, using random effects models. RESULTS: Across all risk factors, an average of 123 cohorts provided data on 1.4 million individuals and 52,000 CVD events. Each metabolic risk factor was robustly related to CVD. At the baseline age of 55-64 years, the RR for 10 mmHg higher SBP was largest for HHD (2.16; 95% CI 2.09-2.24), followed by effects on both stroke subtypes (1.66; 1.39-1.98 for hemorrhagic stroke and 1.63; 1.57-1.69 for ischemic stroke). In the same age group, RRs for 1 mmol/L higher TC were 1.44 (1.29-1.61) for IHD and 1.20 (1.15-1.25) for ischemic stroke. The RRs for 5 kg/m(2) higher BMI for ages 55-64 ranged from 2.32 (2.04-2.63) for diabetes, to 1.44 (1.40-1.48) for IHD. For 1 mmol/L higher FPG, RRs in this age group were 1.18 (1.08-1.29) for IHD and 1.14 (1.01-1.29) for total stroke. For all risk factors, proportional effects declined with age, were generally consistent by sex, and differed by region in only a few age groups for certain risk factor-disease pairs. CONCLUSION: Our results provide robust, comparable and precise estimates of the effects of major metabolic risk factors on CVD and diabetes by age group.
Subject: 3142 Public health care science, environmental and occupational health
diabetes
cardiovascular disease
metabolic risk factors
3121 General medicine, internal medicine and other clinical medicine
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