Predicting Outcome of Childhood Bacterial Meningitis With a Single Measurement of C-Reactive Protein

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http://hdl.handle.net/10138/165211

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Peltola , H , Pelkonen , T , Roine , I , Cruzeiro , M L , Bernardino , L & Latin Amer Meningitis Study Grp 2016 , ' Predicting Outcome of Childhood Bacterial Meningitis With a Single Measurement of C-Reactive Protein ' , Pediatric Infectious Disease Journal , vol. 35 , no. 6 , pp. 617-621 . https://doi.org/10.1097/INF.0000000000001133

Title: Predicting Outcome of Childhood Bacterial Meningitis With a Single Measurement of C-Reactive Protein
Author: Peltola, Heikki; Pelkonen, Tuula; Roine, Irmeli; Cruzeiro, Manuel Leite; Bernardino, Luis; Latin Amer Meningitis Study Grp
Contributor: University of Helsinki, Clinicum
University of Helsinki, Children's Hospital
Date: 2016-06
Language: eng
Number of pages: 5
Belongs to series: Pediatric Infectious Disease Journal
ISSN: 0891-3668
URI: http://hdl.handle.net/10138/165211
Abstract: Introduction: C-reactive protein (CRP), a marker of inflammation, shows high serum levels in invasive bacterial infections. We investigated the potential of a single CRP measurement at different phases of acute childhood bacterial meningitis to predict outcomes. Methods: Using whole-blood finger-prick samples with no centrifugation, CRP was measured quantitatively on arrival and on day 3 or 4 in children participating in 2 prospective, randomized, double-blind treatment studies conducted in Latin America or Angola. The results were compared with patient outcomes. Results: Although initial CRP values from 669 children gave useful prognostic information, the 3rd or 4th day measurements taken from 275 children associated significantly with seizures, slow recovery and low scores on the Glasgow Outcome Scale, with odds ratios for CRP values above the median (62 mg/L) ranging from 2 to 6, 2 to 5, and 3 to 5 (Latin America-Angola), respectively. Hearing impairment, although not full deafness, was 3 to 7 times more likely if CRP was above the median soon after hospitalization. Conclusions: Especially in resource-poor settings, clinicians have few simple-enough tools to identify the child with meningitis who requires maximum attention. CRP is a worthy addition.
Subject: C-reactive protein
bacterial meningitis
childhood
developing
countries
prognosis
CEREBROSPINAL-FLUID
CONJUGATE VACCINE
CONTROLLED-TRIAL
CHILDREN
INFECTIONS
3123 Gynaecology and paediatrics
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