Monosomal karyotype as an adverse prognostic factor in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem-cell transplantation in first complete remission : a retrospective survey on behalf of the ALWP of the EBMT

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dc.contributor University of Helsinki, Department of Medicine en
dc.contributor.author Brands-Nijenhuis, Angelique V. M.
dc.contributor.author Labopin, Myriam
dc.contributor.author Schouten, Harry C.
dc.contributor.author Volin, Liisa
dc.contributor.author Socie, Gerard
dc.contributor.author Cornelissen, Jan J.
dc.contributor.author Huynh, Anne
dc.contributor.author Ljungman, Per
dc.contributor.author Malard, Florent
dc.contributor.author Esteve, Jordi
dc.contributor.author Nagler, Arnon
dc.contributor.author Mohty, Mohamad
dc.date.accessioned 2016-08-04T12:54:01Z
dc.date.available 2016-08-04T12:54:01Z
dc.date.issued 2016-02
dc.identifier.citation Brands-Nijenhuis , A V M , Labopin , M , Schouten , H C , Volin , L , Socie , G , Cornelissen , J J , Huynh , A , Ljungman , P , Malard , F , Esteve , J , Nagler , A & Mohty , M 2016 , ' Monosomal karyotype as an adverse prognostic factor in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem-cell transplantation in first complete remission : a retrospective survey on behalf of the ALWP of the EBMT ' , Haematologica , vol. 101 , no. 2 , pp. 248-255 . https://doi.org/10.3324/haematol.2015.132654 en
dc.identifier.issn 0390-6078
dc.identifier.other PURE: 66854582
dc.identifier.other PURE UUID: 5c1260df-9fbf-41e5-8750-988a62b013eb
dc.identifier.other WOS: 000379156300018
dc.identifier.other Scopus: 84957684108
dc.identifier.uri http://hdl.handle.net/10138/165231
dc.description.abstract Despite the overall benefit from allogeneic hematopoietic stem cell transplantation observed in patients with poor cytogenetic risk acute myeloid leukemia in first complete remission, the precise effect of this procedure for different poor-risk subtypes has not been fully analyzed. This retrospective analysis was performed to investigate whether allogeneic hematopoietic stem cell transplantation performed in first complete remission in patients with monosomal karyotype can overcome the adverse prognosis associated with these patients. Of the 4635 patients included in the study, 189 (4%) harbored a monosomal karyotype. The presence of a monosomal karyotype was associated with a worse outcome, with an inferior leukemia-free survival and overall survival (5-year leukemia-free survival and overall survival: 24 +/- 3% and 26 +/- 3% vs. 53 +/- 1% and 57 +/- 1% in monosomal-karyotype and non-monosomal-karyotype, respectively; P en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Haematologica
dc.rights en
dc.subject IMPACT en
dc.subject 3121 General medicine, internal medicine and other clinical medicine en
dc.title Monosomal karyotype as an adverse prognostic factor in patients with acute myeloid leukemia treated with allogeneic hematopoietic stem-cell transplantation in first complete remission : a retrospective survey on behalf of the ALWP of the EBMT en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.3324/haematol.2015.132654
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
dc.contributor.pbl
dc.contributor.pbl

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