Sun , Z , Harris , H M B , McCann , A , Guo , C , Argimon , S , Zhang , W , Yang , X , Jeffery , I B , Cooney , J C , Kagawa , T F , Liu , W , Song , Y , Salvetti , E , Wrobel , A , Rasinkangas , P , Parkhill , J , Rea , M C , O'Sullivan , O , Ritari , J , Douillard , F P , Ross , R P , Yang , R , Briner , A E , Felis , G E , de Vos , W M , Barrangou , R , Klaenhammer , T R , Caufield , P W , Cui , Y , Zhang , H & O'Toole , P W 2015 , ' Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera ' , Nature Communications , vol. 6 , 8322 . https://doi.org/10.1038/ncomms9322
Title: | Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera |
Author: | Sun, Zhihong; Harris, Hugh M. B.; McCann, Angela; Guo, Chenyi; Argimon, Silvia; Zhang, Wenyi; Yang, Xianwei; Jeffery, Ian B.; Cooney, Jakki C.; Kagawa, Todd F.; Liu, Wenjun; Song, Yuqin; Salvetti, Elisa; Wrobel, Agnieszka; Rasinkangas, Pia; Parkhill, Julian; Rea, Mary C.; O'Sullivan, Orla; Ritari, Jarmo; Douillard, Francois P.; Ross, R. Paul; Yang, Ruifu; Briner, Alexandra E.; Felis, Giovanna E.; de Vos, Willem M.; Barrangou, Rodolphe; Klaenhammer, Todd R.; Caufield, Page W.; Cui, Yujun; Zhang, Heping; O'Toole, Paul W. |
Contributor organization: | Research Programs Unit Departments of Faculty of Veterinary Medicine Veterinary Biosciences Willem Meindert Vos de / Principal Investigator de Vos & Salonen group |
Date: | 2015-09 |
Language: | eng |
Number of pages: | 13 |
Belongs to series: | Nature Communications |
ISSN: | 2041-1723 |
DOI: | https://doi.org/10.1038/ncomms9322 |
URI: | http://hdl.handle.net/10138/165265 |
Abstract: | Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species. |
Subject: |
LACTIC-ACID BACTERIA
CRISPR-CAS SYSTEMS MULTIPLE SEQUENCE ALIGNMENT GLYCOSIDE HYDROLASE FAMILY GRAM-POSITIVE BACTERIA PHYLOGENETIC ANALYSIS GENUS LACTOBACILLUS MOLECULAR-CLONING PROTEIN PROBIOTICS 413 Veterinary science |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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