Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera

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Sun , Z , Harris , H M B , McCann , A , Guo , C , Argimon , S , Zhang , W , Yang , X , Jeffery , I B , Cooney , J C , Kagawa , T F , Liu , W , Song , Y , Salvetti , E , Wrobel , A , Rasinkangas , P , Parkhill , J , Rea , M C , O'Sullivan , O , Ritari , J , Douillard , F P , Ross , R P , Yang , R , Briner , A E , Felis , G E , de Vos , W M , Barrangou , R , Klaenhammer , T R , Caufield , P W , Cui , Y , Zhang , H & O'Toole , P W 2015 , ' Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera ' Nature Communications , vol. 6 , 8322 . DOI: 10.1038/ncomms9322

Title: Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera
Author: Sun, Zhihong; Harris, Hugh M. B.; McCann, Angela; Guo, Chenyi; Argimon, Silvia; Zhang, Wenyi; Yang, Xianwei; Jeffery, Ian B.; Cooney, Jakki C.; Kagawa, Todd F.; Liu, Wenjun; Song, Yuqin; Salvetti, Elisa; Wrobel, Agnieszka; Rasinkangas, Pia; Parkhill, Julian; Rea, Mary C.; O'Sullivan, Orla; Ritari, Jarmo; Douillard, Francois P.; Ross, R. Paul; Yang, Ruifu; Briner, Alexandra E.; Felis, Giovanna E.; de Vos, Willem M.; Barrangou, Rodolphe; Klaenhammer, Todd R.; Caufield, Page W.; Cui, Yujun; Zhang, Heping; O'Toole, Paul W.
Contributor: University of Helsinki, Research Programmes Unit
University of Helsinki, Veterinary Biosciences
University of Helsinki, Veterinary Biosciences
University of Helsinki, Willem Meindert Vos de / Principal Investigator
Date: 2015-09
Language: eng
Number of pages: 13
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/165265
Abstract: Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species.
Subject: LACTIC-ACID BACTERIA
CRISPR-CAS SYSTEMS
MULTIPLE SEQUENCE ALIGNMENT
GLYCOSIDE HYDROLASE FAMILY
GRAM-POSITIVE BACTERIA
PHYLOGENETIC ANALYSIS
GENUS LACTOBACILLUS
MOLECULAR-CLONING
PROTEIN
PROBIOTICS
413 Veterinary science
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