Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

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http://hdl.handle.net/10138/165267

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Lawrenson , K , Li , Q , Kar , S , Seo , J-H , Tyrer , J , Spindler , T J , Lee , J , Chen , Y , Karst , A , Drapkin , R , Aben , K K H , Anton-Culver , H , Antonenkova , N , Baker , H , Bandera , E V , Bean , Y , Beckmann , M W , Berchuck , A , Bisogna , M , Bjorge , L , Bogdanova , N , Brinton , L A , Brooks-Wilson , A , Bruinsma , F , Butzow , R , Campbell , I G , Carty , K , Chang-Claude , J , Chenevix-Trench , G , Chen , A , Chen , Z , Cook , L S , Cramer , D W , Cunningham , J M , Cybulski , C , Dansonka-Mieszkowska , A , Dennis , J , Dicks , E , Doherty , J A , Doerk , T , Du Bois , A , Duerst , M , Eccles , D , Easton , D T , Edwards , R P , Eilber , U , Ekici , A B , Leminen , A , Nevanlinna , H , Pelttari , L M & Australian Ovarian Canc Study Grp 2015 , ' Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer ' Nature Communications , vol. 6 , 8234 . DOI: 10.1038/ncomms9234

Title: Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer
Author: Lawrenson, Kate; Li, Qiyan; Kar, Siddhartha; Seo, Ji-Heui; Tyrer, Jonathan; Spindler, Tassja J.; Lee, Janet; Chen, Yibu; Karst, Alison; Drapkin, Ronny; Aben, Katja K. H.; Anton-Culver, Hoda; Antonenkova, Natalia; Baker, Helen; Bandera, Elisa V.; Bean, Yukie; Beckmann, Matthias W.; Berchuck, Andrew; Bisogna, Maria; Bjorge, Line; Bogdanova, Natalia; Brinton, Louise A.; Brooks-Wilson, Angela; Bruinsma, Fiona; Butzow, Ralf; Campbell, Ian G.; Carty, Karen; Chang-Claude, Jenny; Chenevix-Trench, Georgia; Chen, Anne; Chen, Zhihua; Cook, Linda S.; Cramer, Daniel W.; Cunningham, Julie M.; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; Dennis, Joe; Dicks, Ed; Doherty, Jennifer A.; Doerk, Thilo; Du Bois, Andreas; Duerst, Matthias; Eccles, Diana; Easton, Douglas T.; Edwards, Robert P.; Eilber, Ursula; Ekici, Arif B.; Leminen, Arto; Nevanlinna, Heli; Pelttari, Liisa M.; Australian Ovarian Canc Study Grp
Contributor: University of Helsinki, Department of Pathology
University of Helsinki, Department of Obstetrics and Gynegology
University of Helsinki, Department of Obstetrics and Gynegology
University of Helsinki, Department of Obstetrics and Gynegology
Date: 2015-09
Language: eng
Number of pages: 14
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/165267
Abstract: Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P
Subject: GENOME-WIDE ASSOCIATION
LONG-RANGE INTERACTION
ANALYSES REVEAL
FALLOPIAN-TUBE
RISK LOCI
HOX GENES
IDENTIFICATION
EXPRESSION
BREAST
VARIANTS
3111 Biomedicine
3123 Gynaecology and paediatrics
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