Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients : a new classification from the European Society for Blood and Marrow Transplantation

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http://hdl.handle.net/10138/165281

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Mohty , M , Malard , F , Abecassis , M , Aerts , E , Alaskar , A S , Aljurf , M , Arat , M , Bader , P , Baron , F , Bazarbachi , A , Blaise , D , Ciceri , F , Corbacioglu , S , Dalle , J-H , Dignan , F , Fukuda , T , Huynh , A , Masszi , T , Michallet , M , Nagler , A , NiChonghaile , M , Okamoto , S , Pagliuca , A , Peters , C , Petersen , F B , Richardson , P G , Ruutu , T , Savani , B N , Wallhult , E , Yakoub-Agha , I , Duarte , R F & Carreras , E 2016 , ' Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients : a new classification from the European Society for Blood and Marrow Transplantation ' Bone Marrow Transplantation , vol. 51 , no. 7 , pp. 906-912 . DOI: 10.1038/bmt.2016.130

Title: Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients : a new classification from the European Society for Blood and Marrow Transplantation
Author: Mohty, M.; Malard, F.; Abecassis, M.; Aerts, E.; Alaskar, A. S.; Aljurf, M.; Arat, M.; Bader, P.; Baron, F.; Bazarbachi, A.; Blaise, D.; Ciceri, F.; Corbacioglu, S.; Dalle, J-H; Dignan, F.; Fukuda, T.; Huynh, A.; Masszi, T.; Michallet, M.; Nagler, A.; NiChonghaile, M.; Okamoto, S.; Pagliuca, A.; Peters, C.; Petersen, F. B.; Richardson, P. G.; Ruutu, T.; Savani, B. N.; Wallhult, E.; Yakoub-Agha, I.; Duarte, R. F.; Carreras, E.
Contributor: University of Helsinki, Department of Medicine
Date: 2016-07
Language: eng
Number of pages: 7
Belongs to series: Bone Marrow Transplantation
ISSN: 0268-3369
URI: http://hdl.handle.net/10138/165281
Abstract: Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (480%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.
Subject: HEPATIC VENOOCCLUSIVE-DISEASE
STEM-CELL TRANSPLANTATION
TISSUE-PLASMINOGEN ACTIVATOR
HIGH-RISK POPULATION
VERSUS-HOST-DISEASE
MR-IMAGING FINDINGS
CONDITIONING REGIMEN
VENOCCLUSIVE DISEASE
SIGNIFICANT TOXICITY
MULTIORGAN FAILURE
3122 Cancers
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