Lactobacillus plantarum WCFS1 and its host interaction : a dozen years after the genome

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http://hdl.handle.net/10138/165282

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van den Nieuwboer , M , van Hemert , S , Claassen , E & de Vos , W M 2016 , ' Lactobacillus plantarum WCFS1 and its host interaction : a dozen years after the genome ' , Microbial Biotechnology , vol. 9 , no. 4 , pp. 452-465 . https://doi.org/10.1111/1751-7915.12368

Title: Lactobacillus plantarum WCFS1 and its host interaction : a dozen years after the genome
Author: van den Nieuwboer, Maurits; van Hemert, Saskia; Claassen, Eric; de Vos, Willem M.
Contributor: University of Helsinki, Medicum
Date: 2016-07
Language: eng
Number of pages: 14
Belongs to series: Microbial Biotechnology
ISSN: 1751-7907
URI: http://hdl.handle.net/10138/165282
Abstract: Lactobacillus plantarum WCFS1 is one of the best studied Lactobacilli, notably as its genome was unravelled over 12years ago. L.plantarum WCFS1 can be grown to high densities, is amenable to genetic transformation and highly robust with a relatively high survival rate during the gastrointestinal passage. In this review, we present and discuss the main insights provided by the functional genomics research on L.plantarum WCFS1 with specific attention for the molecular mechanisms related to its interaction with the human host and its potential to modify the immune system, and induce other health-related benefits. Whereas most insight has been gained in mouse and other model studies, onlyfive human studies have been reported with L.plantarum WCFS1. Hence NCIMB 8826 (the parental strain of L.plantarum WCFS1) in human trials as to capitalize on the wealth of knowledge that is summarized here.
Subject: LACTIC-ACID BACTERIA
HUMAN GASTROINTESTINAL-TRACT
AGGREGATION-PROMOTING FACTOR
GRAM-POSITIVE BACTERIA
BILE-SALT HYDROLASE
IN-VIVO
FUNCTIONAL-ANALYSIS
ACIDOPHILUS NCFM
TIGHT JUNCTION
RHAMNOSUS GG
3111 Biomedicine
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