Childhood adversities and adult-onset asthma: a cohort study

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dc.contributor University of Helsinki, Hjelt Institute (-2014) en
dc.contributor University of Helsinki, Hjelt Institute (-2014) en
dc.contributor.author Korkeila, Jyrki
dc.contributor.author Lietzen, Raija
dc.contributor.author Sillanmäki, Lauri Henrik
dc.contributor.author Rautava, Päivi
dc.contributor.author Korkeila, Katariina
dc.contributor.author Kivimäki, Mika
dc.contributor.author Koskenvuo, Markku
dc.contributor.author Vahtera, Jussi
dc.date.accessioned 2016-08-08T13:11:01Z
dc.date.available 2016-08-08T13:11:01Z
dc.date.issued 2012
dc.identifier.citation Korkeila , J , Lietzen , R , Sillanmäki , L H , Rautava , P , Korkeila , K , Kivimäki , M , Koskenvuo , M & Vahtera , J 2012 , ' Childhood adversities and adult-onset asthma: a cohort study ' , BMJ Open , vol. 2 , no. 5 , pp. e001625 . https://doi.org/10.1136/bmjopen-2012-001625 en
dc.identifier.issn 2044-6055
dc.identifier.other PURE: 23964199
dc.identifier.other PURE UUID: 029b0a40-173c-44b6-bed0-23de1145186d
dc.identifier.other WOS: 000315053900097
dc.identifier.other Scopus: 84869752178
dc.identifier.uri http://hdl.handle.net/10138/165360
dc.description.abstract OBJECTIVES: Childhood adversities may be important determinants of later illnesses and poor health behaviour. However, large-scale prospective studies on the associations between childhood adversities and the onset of asthma in adulthood are lacking. DESIGN: Prospective cohort study with 7-year follow-up. SETTING: Nationally representative study. Data were collected from the Health and Social Support (HeSSup) survey and national registers. PARTICIPANTS: The participants represent the Finnish population from the following age groups: 20-24, 30-34, 40-44, and 50-54 years at baseline in 1998 (24 057 survey participants formed the final cohort of this study). The occurrence of childhood adversities was assessed at baseline with a six-item survey scale. The analyses were adjusted for sociodemographic characteristics, behavioural health risks and common mental disorders. PRIMARY AND SECONDARY OUTCOMES: The survey data were linked to data from national health registers on incident asthma during a 7-year follow-up to define new-onset asthma cases with verified diagnoses. RESULTS: A total of 12 126 (59%) participants reported that they encountered a childhood adversity. Of them 3677 (18% of all) endured three to six adversities. During a follow-up of 7 years, 593 (2.9%) participants were diagnosed with incident asthma. Those who reported three or more childhood adversities had a 1.6-fold (95% CI 1.31 to 2.01) greater risk of asthma compared to those without childhood adversities. This hazard attenuated but remained statistically significant after adjustment for conventional risk factors (HR 1.33; 95% CI 1.06 to 1.67). CONCLUSIONS: Adults who report having encountered adversities in childhood may have an increased risk of developing asthma. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof BMJ Open
dc.rights en
dc.subject 3142 Public health care science, environmental and occupational health en
dc.subject asthma en
dc.subject CHILDHOOD ADVERSITIES en
dc.subject ADULT-ONSET ASTHMA en
dc.title Childhood adversities and adult-onset asthma: a cohort study en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1136/bmjopen-2012-001625
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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