Microbial secondary metabolites in homes in association with moisture damage and asthma

Show full item record



Permalink

http://hdl.handle.net/10138/165871

Citation

Kirjavainen , P V , Taubel , M , Karvonen , A M , Sulyok , M , Tiittanen , P , Krska , R , Hyvarinen , A & Pekkanen , J 2016 , ' Microbial secondary metabolites in homes in association with moisture damage and asthma ' , Indoor Air , vol. 26 , no. 3 , pp. 448-456 . https://doi.org/10.1111/ina.12213

Title: Microbial secondary metabolites in homes in association with moisture damage and asthma
Author: Kirjavainen, P. V.; Taubel, M.; Karvonen, A. M.; Sulyok, M.; Tiittanen, P.; Krska, R.; Hyvarinen, A.; Pekkanen, J.
Contributor: University of Helsinki, Clinicum
Date: 2016-06
Language: eng
Number of pages: 9
Belongs to series: Indoor Air
ISSN: 0905-6947
URI: http://hdl.handle.net/10138/165871
Abstract: We aimed to characterize the presence of microbial secondary metabolites in homes and their association with moisture damage, mold, and asthma development. Living room floor dust was analyzed by LC-MS/MS for 333 secondary metabolites from 93 homes of 1-year-old children. Moisture damage was present in 15 living rooms. At 6 years, 8 children had active and 15 lifetime doctor-diagnosed asthma. The median number of different metabolites per house was 17 ( range 8-29) and median sum load 65 ( 4-865) ng/m(2). Overall 42 different metabolites were detected. The number of metabolites present tended to be higher in homes with mold odor or moisture damage. The higher sum loads and number of metabolites with loads over 10 ng/m(2) were associated with lower prevalence of active asthma at 6 years ( aOR 0.06 ( 95% CI <0.001-0.96) and 0.05 (<0.001-0.56), respectively). None of the individual metabolites, which presence tended ( P <0.2) to be increased by moisture damage or mold, were associated with increased risk of asthma. Microbial secondary metabolites are ubiquitously present in home floor dust. Moisture damage and mold tend to increase their numbers and amount. There was no evidence indicating that the secondary metabolites determined would explain the association between moisture damage, mold, and the development of asthma.
Subject: Asthma
Mycotoxins
Secondary metabolites
Moisture damage
Molds
INDOOR ENVIRONMENTS
MASS-SPECTROMETRY
CHILDHOOD ASTHMA
BIRTH-COHORT
SATRATOXIN-G
MYCOTOXINS
STACHYBOTRYS
BUILDINGS
EXPOSURE
SYMPTOMS
3142 Public health care science, environmental and occupational health
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
ina12213.pdf 601.4Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record