The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendages in amniotes

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dc.contributor University of Helsinki, Institute of Biotechnology en
dc.contributor.author Di Poi, Nicholas
dc.contributor.author Milinkovitch, Michel
dc.date.accessioned 2016-08-16T13:23:02Z
dc.date.available 2016-08-16T13:23:02Z
dc.date.issued 2016-06-24
dc.identifier.citation Di Poi , N & Milinkovitch , M 2016 , ' The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendages in amniotes ' , Science Advances , vol. 2 , no. 6 , e1600708 . https://doi.org/10.1126/sciadv.1600708 en
dc.identifier.issn 2375-2548
dc.identifier.other PURE: 65905461
dc.identifier.other PURE UUID: 00b081c6-a540-43cb-a535-25f18621d490
dc.identifier.other WOS: 000380073800036
dc.identifier.other Scopus: 84992555353
dc.identifier.other ORCID: /0000-0002-3313-3016/work/29213195
dc.identifier.uri http://hdl.handle.net/10138/165876
dc.description.abstract Most mammals, birds, and reptiles are readily recognized by their hairs, feathers, and scales, respectively. However, the lack of fossil intermediate forms between scales and hairs and substantial differences in their morphogenesis and protein composition have fueled the controversy pertaining to their potential common ancestry for decades. Central to this debate is the apparent lack of an “anatomical placode” (that is, a local epidermal thickening characteristic of feathers’ and hairs’ early morphogenesis) in reptile scale development. Hence, scenarios have been proposed for the independent development of the anatomical placode in birds and mammals and parallel co-option of similar signaling pathways for their morphogenesis. Using histological and molecular techniques on developmental series of crocodiles and snakes, as well as of unique wild-type and EDA (ectodysplasin A)–deficient scaleless mutant lizards, we show for the first time that reptiles, including crocodiles and squamates, develop all the characteristics of an anatomical placode: columnar cells with reduced proliferation rate, as well as canonical spatial expression of placode and underlying dermal molecular markers. These results reveal a new evolutionary scenario where hairs, feathers, and scales of extant species are homologous structures inherited, with modification, from their shared reptilian ancestor’s skin appendages already characterized by an anatomical placode and associated signaling molecules. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Science Advances
dc.relation.uri http://advances.sciencemag.org/content/2/6/e1600708
dc.rights en
dc.subject 1181 Ecology, evolutionary biology en
dc.title The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendages in amniotes en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1126/sciadv.1600708
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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