Cardiac fibrosis in myocardial infarction - from repair and remodeling to regeneration

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dc.contributor University of Helsinki, Faculty of Pharmacy en
dc.contributor University of Helsinki, Faculty of Pharmacy en
dc.contributor.author Talman, Virpi
dc.contributor.author Ruskoaho, Heikki Juhani
dc.date.accessioned 2016-09-07T08:30:01Z
dc.date.available 2016-09-07T08:30:01Z
dc.date.issued 2016-09-01
dc.identifier.citation Talman , V & Ruskoaho , H J 2016 , ' Cardiac fibrosis in myocardial infarction - from repair and remodeling to regeneration ' , Cell and Tissue Research , vol. 365 , no. 3 , pp. 563-581 . https://doi.org/10.1007/s00441-016-2431-9 en
dc.identifier.issn 0302-766X
dc.identifier.other PURE: 65372218
dc.identifier.other PURE UUID: 365842b9-9f0a-42c0-8cd1-9e6b950f28af
dc.identifier.other Scopus: 84975230737
dc.identifier.other WOS: 000382671300011
dc.identifier.other ORCID: /0000-0002-2702-6505/work/28954863
dc.identifier.other ORCID: /0000-0001-8971-1359/work/29919044
dc.identifier.uri http://hdl.handle.net/10138/166517
dc.description.abstract Ischemic cell death during a myocardial infarction leads to a multiphase reparative response in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and myofibroblasts. This also induces geometrical, biomechanical, and biochemical changes in the uninjured ventricular wall eliciting a reactive remodeling process that includes interstitial and perivascular fibrosis. Although the initial reparative fibrosis is crucial for preventing rupture of the ventricular wall, an exaggerated fibrotic response and reactive fibrosis outside the injured area are detrimental as they lead to progressive impairment of cardiac function and eventually to heart failure. In this review, we summarize current knowledge of the mechanisms of both reparative and reactive cardiac fibrosis in response to myocardial infarction, discuss the potential of inducing cardiac regeneration through direct reprogramming of fibroblasts and myofibroblasts into cardiomyocytes, and review the currently available and potential future therapeutic strategies to inhibit cardiac fibrosis. en
dc.format.extent 19
dc.language.iso eng
dc.relation.ispartof Cell and Tissue Research
dc.relation.uri http://rdcu.be/j6uC
dc.rights en
dc.subject 317 Pharmacy en
dc.title Cardiac fibrosis in myocardial infarction - from repair and remodeling to regeneration en
dc.type Review Article
dc.identifier.doi https://doi.org/10.1007/s00441-016-2431-9
dc.type.uri info:eu-repo/semantics/other
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