Quantitative trait locus analysis of body shape divergence in nine-spined sticklebacks based on high-density SNP-panel

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Yang , J , Guo , B , Shikano , T , Liu , X & Merilä , J 2016 , ' Quantitative trait locus analysis of body shape divergence in nine-spined sticklebacks based on high-density SNP-panel ' , Scientific Reports , vol. 6 , 26632 . https://doi.org/10.1038/srep26632

Title: Quantitative trait locus analysis of body shape divergence in nine-spined sticklebacks based on high-density SNP-panel
Author: Yang, Jing; Guo, Baocheng; Shikano, Takahito; Liu, Xiaolin; Merilä, Juha
Contributor: University of Helsinki, Biosciences
University of Helsinki, Biosciences
University of Helsinki, Biosciences
Date: 2016-05-26
Language: eng
Number of pages: 16
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/166553
Abstract: Heritable phenotypic differences between populations, caused by the selective effects of distinct environmental conditions, are of commonplace occurrence in nature. However, the actual genomic targets of this kind of selection are still poorly understood. We conducted a quantitative trait locus (QTL) mapping study to identify genomic regions responsible for morphometric differentiation between genetically and phenotypically divergent marine and freshwater nine-spined stickleback (Pungitius pungitius) populations. Using a dense panel of SNP-markers obtained by restriction site associated DNA sequencing of an F-2 recombinant cross, we found 22 QTL that explained 3.5-12.9% of phenotypic variance in the traits under investigation. We detected one fairly large-effect (PVE = 9.6%) QTL for caudal peduncle length-a trait with a well-established adaptive function showing clear differentiation among marine and freshwater populations. We also identified two large-effect QTL for lateral plate numbers, which are different from the lateral plate QTL reported in earlier studies of this and related species. Hence, apart from identifying several large-effect QTL in shape traits showing adaptive differentiation in response to different environmental conditions, the results suggest intra-and interspecific heterogeneity in the genomic basis of lateral plate number variation.
Subject: WHITEFISH COREGONUS-CLUPEAFORMIS
GENERATION SEQUENCING DATA
THREESPINE STICKLEBACK
GENETIC ARCHITECTURE
PUNGITIUS-PUNGITIUS
GASTEROSTEUS-ACULEATUS
PARALLEL EVOLUTION
NEXT-GENERATION
3-SPINED STICKLEBACK
PELVIC REDUCTION
1181 Ecology, evolutionary biology
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