Phospholipids and insulin resistance in psychosis : a lipidomics study of twin pairs discordant for schizophrenia

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http://hdl.handle.net/10138/166576

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Oresic , M , Seppänen-Laakso , T , Sun , D , Tang , J , Therman , S , Viehman , R , Mustonen , U , van Erp , T G M , Hyötyläinen , T , Thompson , P , Toga , A W , Huttunen , M O , Suvisaari , J , Kaprio , J , Lönnqvist , J & Cannon , T D 2012 , ' Phospholipids and insulin resistance in psychosis : a lipidomics study of twin pairs discordant for schizophrenia ' , Genome medicine , vol. 4 , no. 1 . https://doi.org/10.1186/gm300

Title: Phospholipids and insulin resistance in psychosis : a lipidomics study of twin pairs discordant for schizophrenia
Author: Oresic, Matej; Seppänen-Laakso, Tuulikki; Sun, Daqiang; Tang, Jing; Therman, Sebastian; Viehman, Rachael; Mustonen, Ulla; van Erp, Theo G.M.; Hyötyläinen, Tuulia; Thompson, Paul; Toga, Arthur W.; Huttunen, Matti O.; Suvisaari, Jaana; Kaprio, Jaakko; Lönnqvist, Jouko; Cannon, Tyrone D.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Hjelt Institute (-2014)
University of Helsinki, Department of Psychiatry
Date: 2012
Language: eng
Number of pages: 11
Belongs to series: Genome medicine
ISSN: 1756-994X
URI: http://hdl.handle.net/10138/166576
Abstract: BACKGROUND: Several theories have been proposed to conceptualize the pathological processes inherent to schizophrenia. The "prostaglandin deficiency" hypothesis postulates that defective enzyme systems converting essential fatty acids to prostaglandins lead to diminished levels of prostaglandins, which in turn affect synaptic transmission. METHODS: Herein we sought to determine the lipidomic profiles associated with schizophrenia in twin pairs discordant for schizophrenia as well as unaffected twin pairs. The study included serum samples from 19 twin pairs discordant for schizophrenia (mean age 51 +/- 10 years; 7 monozygotic pairs; 13 female pairs) and 34 age and gender matched healthy twins as controls. Neurocognitive assessment data and gray matter density measurements taken from high-resolution magnetic resonance images were also obtained. Lipidomics platform using Ultra Performance Liquid Chromatography coupled to time-of-flight mass spectrometry was applied for the analysis of serum samples. RESULTS: In comparison to their healthy co-twins, the patients had elevated triglycerides and were more insulin resistant. They had diminished lysophosphatidylcholine levels which associated with decreased cognitive speed. CONCLUSIONS: Our findings may be of pathophysiological relevance since lysophosphatidylcholines, byproducts of phospholipase A2-catalyzed phospholipid hydrolysis, are preferred carriers of polyunsaturated fatty acids across the blood-brain barrier. Furthermore, diminishment of lysophosphatidylcholines suggests that subjects at risk of schizophrenia may be more susceptible to infections. Their association with cognitive speed supports the view that altered neurotransmission in schizophrenia may be in part mediated by reactive lipids such as prostaglandins.
Subject: 3142 Public health care science, environmental and occupational health
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