Effect of Breed on Plasma Endothelin-1 Concentration, Plasma Renin Activity, and Serum Cortisol Concentration in Healthy Dogs

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Hoglund , K , Lequarre , A -S , Ljungvall , I , Mc Entee , K , Merveille , A -C , Wiberg , M , Gouni , V , Willesen , J L , Hanas , S , Wess , G , Sorensen , L M , Tiret , L , Kierczak , M , Forsberg , S K G , Seppälä , E , Lindblad-Toh , K , Lohi , H , Chetboul , V , Fredholm , M & Haggstrom , J 2016 , ' Effect of Breed on Plasma Endothelin-1 Concentration, Plasma Renin Activity, and Serum Cortisol Concentration in Healthy Dogs ' Journal of Veterinary Internal Medicine , vol. 30 , no. 2 , pp. 566-573 . DOI: 10.1111/jvim.13829

Title: Effect of Breed on Plasma Endothelin-1 Concentration, Plasma Renin Activity, and Serum Cortisol Concentration in Healthy Dogs
Author: Hoglund, K.; Lequarre, A. -S.; Ljungvall, I.; Mc Entee, K.; Merveille, A. -C.; Wiberg, M.; Gouni, V.; Willesen, J. Lundgren; Hanas, S.; Wess, G.; Sorensen, L. Mejer; Tiret, L.; Kierczak, M.; Forsberg, S. K. G.; Seppälä, E.; Lindblad-Toh, K.; Lohi, H.; Chetboul, V.; Fredholm, M.; Haggstrom, J.
Contributor: University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Department of Medicine
University of Helsinki, Veterinary Biosciences
Date: 2016
Language: eng
Number of pages: 8
Belongs to series: Journal of Veterinary Internal Medicine
ISSN: 0891-6640
URI: http://hdl.handle.net/10138/166583
Abstract: BackgroundThere are breed differences in several blood variables in healthy dogs. ObjectiveInvestigate breed variation in plasma endothelin-1 (ET-1) concentration, plasma renin activity, and serum cortisol concentration. AnimalsFive-hundred and thirty-one healthy dogs of 9 breeds examined at 5 centers (2-4 breeds/center). MethodsProspective observational study. Circulating concentrations of ET-1 and cortisol, and renin activity, were measured using commercially available assays. Absence of organ-related or systemic disease was ensured by thorough clinical investigations, including blood pressure measurement, echocardiography, ECG, blood and urine analysis. ResultsMedian ET-1 concentration was 1.29 (interquartile range [IQR], 0.97-1.82) pg/mL, median cortisol concentration 46.0 (IQR, 29.0-80.8) nmol/L, and median renin activity 0.73 (IQR, 0.48-1.10) ng/mL/h in all dogs. Overall, breed differences were found in ET-1 and cortisol concentrations, and renin activity (P <.0001 for all). Pair-wise comparisons between breeds differed in 67% of comparisons for ET-1, 22% for cortisol, and 19% for renin activity, respectively. Within centers, breed differences were found at 5/5 centers for ET-1, 4/5 centers for cortisol, and 2/5 centers for renin activity. Newfoundlands had highest median ET-1 concentration, 3 times higher than Cavalier King Charles Spaniels, Doberman Pinschers, and Dachshunds. Median renin activity was highest in Dachshunds, twice the median value in Newfoundlands and Boxers. Median cortisol concentration was highest in Finnish Lapphunds, almost 3 times higher than in Boxers. Conclusions and Clinical ImportanceBreed variation might be important to take into consideration when interpreting test results in clinical studies.
Subject: Biomarker
Breed variation
Canine
Vasoactive
ANGIOTENSIN-ALDOSTERONE SYSTEM
ATRIAL-NATRIURETIC-PEPTIDE
CONGESTIVE-HEART-FAILURE
KING CHARLES SPANIELS
BLOOD-PRESSURE
DILATED CARDIOMYOPATHY
CARDIAC-DISEASE
MESSENGER-RNA
BODY-WEIGHT
AGE
413 Veterinary science
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