Oral cobalamin supplementation in dogs with chronic enteropathies and hypocobalaminemia

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Toresson , L , Steiner , J M , Suchodolski , J S & Spillmann , T 2016 , ' Oral cobalamin supplementation in dogs with chronic enteropathies and hypocobalaminemia ' , Journal of Veterinary Internal Medicine , vol. 30 , no. 1 , pp. 101-107 . https://doi.org/10.1111/jvim.13797

Title: Oral cobalamin supplementation in dogs with chronic enteropathies and hypocobalaminemia
Author: Toresson, L.; Steiner, J. M.; Suchodolski, J. S.; Spillmann, T.
Contributor: University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Departments of Faculty of Veterinary Medicine
Date: 2016
Language: eng
Number of pages: 7
Belongs to series: Journal of Veterinary Internal Medicine
ISSN: 0891-6640
URI: http://hdl.handle.net/10138/166584
Abstract: Background: Cobalamin deficiency is commonly associated with chronic enteropathies (CE) in dogs and current treatment protocols recommend parenteral supplementation. In humans, several studies have reported equal efficacy of oral and parenteral cobalamin administration of cobalamin. Objectives: To retrospectively evaluate whether oral cobalamin supplementation can restore normocobalaminemia in dogs with CE and hypocobalaminemia. Animals: Fifty-one client-owned dogs with various signs of CE and hypocobalaminemia. Material and Methods: Retrospective study based on a computerized database search for dogs treated at Evidensia Specialist Animal Hospital, Helsingborg, Sweden during January 2012-March 2014. Inclusion criteria were dogs with signs of CE, an initial serum cobalamin Results: All dogs became normocobalaminemic with oral cobalamin supplementation. The mean increase in serum cobalamin concentration after treatment was 794 +/- 462 ng/L. Serum cobalamin concentrations were significantly higher after supplementation (mean 1017 +/- 460 ng/L; P <.0001) than at baseline (mean 223 +/- 33 ng/L). Conclusion and Clinical Importance: Our results suggest that oral cobalamin supplementation is effective in normalizing serum cobalamin concentrations in dogs with CE. Prospective studies comparing cellular cobalamin status in dogs being treated with parenteral versus oral cobalamin supplementation are warranted before oral supplementation can be recommended for routine supplementation.
Subject: Inflammatory Bowel Disease
Oral supplementation
Vitamin B12
INFLAMMATORY-BOWEL-DISEASE
METHYLMALONIC ACID CONCENTRATIONS
PERNICIOUS-ANEMIA
INTRINSIC-FACTOR
SERUM COBALAMIN
VITAMIN B12
OPEN-LABEL
DEFICIENCY
DIAGNOSIS
THERAPY
413 Veterinary science
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