LGI Proteins and Epilepsy in Human and Animals

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Pakozdy , A , Patzl , M , Zimmermann , L , Jokinen , T S , Glantschnigg , U , Kelemen , A & Hasegawa , D 2015 , ' LGI Proteins and Epilepsy in Human and Animals ' , Journal of Veterinary Internal Medicine , vol. 29 , no. 4 , pp. 997-1005 . https://doi.org/10.1111/jvim.12610

Title: LGI Proteins and Epilepsy in Human and Animals
Author: Pakozdy, A.; Patzl, M.; Zimmermann, L.; Jokinen, T. S.; Glantschnigg, U.; Kelemen, A.; Hasegawa, D.
Contributor: University of Helsinki, Departments of Faculty of Veterinary Medicine
Date: 2015
Language: eng
Number of pages: 9
Belongs to series: Journal of Veterinary Internal Medicine
ISSN: 0891-6640
URI: http://hdl.handle.net/10138/166585
Abstract: Leucine-rich glioma-inactivated (LGI) protein was first thought to have a suppressor effect in the formation of some cancers. Developments in physiology and medicine made it possible to characterize the function of the LGI protein family and its crucial role in different conditions more precisely. These proteins play an important role in synaptic transmission, and dysfunction may cause hyperexcitability. Genetic mutation of LGI1 was confirmed to be the cause of autosomal dominant lateral temporal lobe epilepsy in humans. The LGI2 mutation was identified in benign familial juvenile epilepsy in Lagotto Romagnolo (LR) dogs. Cats with familial spontaneous temporal lobe epilepsy have been reported, and the etiology might be associated with LGI protein family dysfunction. In addition, an autoimmune reaction against LGI1 was detected in humans and cats with limbic encephalitis. These advances prompted a review of LGI protein function and its role in different seizure disorders.
Subject: Autoimmune
Epilepsy
Genetic
LGI
TEMPORAL-LOBE EPILEPSY
DOMINANT PARTIAL EPILEPSY
GLIOMA INACTIVATED 3
POTASSIUM CHANNEL ANTIBODIES
LAGOTTO-ROMAGNOLO DOGS
LIMBIC ENCEPHALITIS
AUTOSOMAL-DOMINANT
LEUCINE-RICH
SYNAPTIC-TRANSMISSION
AUDITORY FEATURES
413 Veterinary science
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