Behavioral Abnormalities in Lagotto Romagnolo Dogs with a History of Benign Familial Juvenile Epilepsy : A Long-Term Follow-Up Study

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Jokinen , T S , Tiira , K , Metsähonkala , L , Seppala , E H , Hielm-Bjorkman , A , Lohi , H & Laitinen-Vapaavuori , O 2015 , ' Behavioral Abnormalities in Lagotto Romagnolo Dogs with a History of Benign Familial Juvenile Epilepsy : A Long-Term Follow-Up Study ' , Journal of Veterinary Internal Medicine , vol. 29 , no. 4 , pp. 1081-1087 . https://doi.org/10.1111/jvim.12611

Title: Behavioral Abnormalities in Lagotto Romagnolo Dogs with a History of Benign Familial Juvenile Epilepsy : A Long-Term Follow-Up Study
Author: Jokinen, T. S.; Tiira, K.; Metsähonkala, L.; Seppala, E. H.; Hielm-Bjorkman, A.; Lohi, H.; Laitinen-Vapaavuori, O.
Contributor: University of Helsinki, Departments of Faculty of Veterinary Medicine
University of Helsinki, Departments of Faculty of Veterinary Medicine
University of Helsinki, Children's Hospital
University of Helsinki, Hannes Tapani Lohi / Principal Investigator
University of Helsinki, Departments of Faculty of Veterinary Medicine
University of Helsinki, Research Programs Unit
University of Helsinki, Departments of Faculty of Veterinary Medicine
Date: 2015
Language: eng
Number of pages: 7
Belongs to series: Journal of Veterinary Internal Medicine
ISSN: 0891-6640
URI: http://hdl.handle.net/10138/166586
Abstract: BackgroundLagotto Romagnolo (LR) dogs with benign juvenile epilepsy syndrome often experience spontaneous remission of seizures. The long-term outcome in these dogs currently is unknown. In humans, behavioral and psychiatric comorbidities have been reported in pediatric and adult-onset epilepsies. Hypothesis/ObjectivesThe objectives of this study were to investigate possible neurobehavioral comorbidities in LR with a history of benign familial juvenile epilepsy (BFJE) and to assess the occurrence of seizures after the remission of seizures in puppyhood. AnimalsA total of 25 LR with a history of BFJE and 91 control dogs of the same breed. MethodsOwners of the LR dogs in the BFJE and control groups completed an online questionnaire about each dog's activity, impulsivity, and inattention. Principal component analysis (PCA) served to extract behavioral factors from the data. We then compared the scores of these factors between the 2 groups in a retrospective case-control study. We also interviewed all dog owners in the BFJE group by telephone to inquire specifically about possible seizures or other neurological problems after remission of seizures as a puppy. ResultsLagotto Romagnolo dogs with BFJE showed significantly higher scores on the factors Inattention and Excitability/Impulsivity than did the control group (P=.003; P=.021, respectively). Only 1 of the 25 BFJE LR exhibited seizures after remission of epilepsy in puppyhood. Conclusions and Clinical ImportanceAlthough the long-term seizure outcome in BFJE LR seems to be good, the dogs exhibit behavioral abnormalities resembling attention deficit hyperactivity disorder (ADHD) in humans, thus suggesting neurobehavioral comorbidities with epilepsy.
Subject: Comorbidity
Epilepsy
Excitability
Impulsivity
NONFUNCTIONING PITUITARY-ADENOMAS
SOMATOSTATIN ANALOG SOM230
GROWTH-FACTOR-I
DIABETES-MELLITUS
INSULIN SENSITIVITY
GENE-EXPRESSION
CATS
HORMONE
PASIREOTIDE
OCTREOTIDE
413 Veterinary science
3112 Neurosciences
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