Conservation of transcription factor binding specificities across 600 million years of bilateria evolution

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Nitta , K R , Jolma , A , Yin , Y , Morgunova , E , Kivioja , T , Akhtar , J , Hens , K , Toivonen , J , Deplancke , B , Furlong , E E M & Taipale , J 2015 , ' Conservation of transcription factor binding specificities across 600 million years of bilateria evolution ' , eLife , vol. 4 , 04837 . https://doi.org/10.7554/eLife.04837

Title: Conservation of transcription factor binding specificities across 600 million years of bilateria evolution
Author: Nitta, Kazuhiro R.; Jolma, Arttu; Yin, Yimeng; Morgunova, Ekaterina; Kivioja, Teemu; Akhtar, Junaid; Hens, Korneel; Toivonen, Jarkko; Deplancke, Bart; Furlong, Eileen E. M.; Taipale, Jussi
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
University of Helsinki, Department of Computer Science
University of Helsinki, Research Programs Unit
Date: 2015-03-17
Language: eng
Number of pages: 20
Belongs to series: eLife
ISSN: 2050-084X
URI: http://hdl.handle.net/10138/166769
Abstract: Divergent morphology of species has largely been ascribed to genetic differences in the tissue-specific expression of proteins, which could be achieved by divergence in cis-regulatory elements or by altering the binding specificity of transcription factors (TFs). The relative importance of the latter has been difficult to assess, as previous systematic analyses of TF binding specificity have been performed using different methods in different species. To address this, we determined the binding specificities of 242 Drosophila TFs, and compared them to human and mouse data. This analysis revealed that TF binding specificities are highly conserved between Drosophila and mammals, and that for orthologous TFs, the similarity extends even to the level of very subtle dinucleotide binding preferences. The few human TFs with divergent specificities function in cell types not found in fruit flies, suggesting that evolution of TF specificities contributes to emergence of novel types of differentiated cells.
Subject: ENDOGENOUS RETROVIRUSES
NUCLEAR RECEPTORS
DNA RECOGNITION
GENE-REGULATION
ETS-FAMILY
HOX GENES
DROSOPHILA
PROTEIN
EXPRESSION
DIVERSITY
1184 Genetics, developmental biology, physiology
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