Alveolar gas exchange and tissue oxygenation during incremental treadmill exercise, and their associations with blood O(2) carrying capacity

Show simple item record

dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Clinicum en
dc.contributor.author Rissanen, Antti-Pekka E.
dc.contributor.author Tikkanen, Heikki O.
dc.contributor.author Koponen, Anne S.
dc.contributor.author Aho, Jyrki M.
dc.contributor.author Hägglund, Harriet
dc.contributor.author Lindholm, Harri
dc.contributor.author Peltonen, Juha E.
dc.date.accessioned 2016-09-16T10:24:01Z
dc.date.available 2016-09-16T10:24:01Z
dc.date.issued 2012-07-11
dc.identifier.citation Rissanen , A-P E , Tikkanen , H O , Koponen , A S , Aho , J M , Hägglund , H , Lindholm , H & Peltonen , J E 2012 , ' Alveolar gas exchange and tissue oxygenation during incremental treadmill exercise, and their associations with blood O(2) carrying capacity ' , Frontiers in Physiology , vol. 3 , no. 265 . en
dc.identifier.issn 1664-042X
dc.identifier.other PURE: 28378166
dc.identifier.other PURE UUID: a93028ab-0472-41f3-9bd2-f2a022983d53
dc.identifier.other WOS: 000209173000259
dc.identifier.other Scopus: 84866549114
dc.identifier.other ORCID: /0000-0002-9158-3752/work/79876498
dc.identifier.uri http://hdl.handle.net/10138/166786
dc.description.abstract The magnitude and timing of oxygenation responses in highly active leg muscle, less active arm muscle, and cerebral tissue, have not been studied with simultaneous alveolar gas exchange measurement during incremental treadmill exercise. Nor is it known, if blood O(2) carrying capacity affects the tissue-specific oxygenation responses. Thus, we investigated alveolar gas exchange and tissue (m. vastus lateralis, m. biceps brachii, cerebral cortex) oxygenation during incremental treadmill exercise until volitional fatigue, and their associations with blood O(2) carrying capacity in 22 healthy men. Alveolar gas exchange was measured, and near-infrared spectroscopy (NIRS) was used to monitor relative concentration changes in oxy- (Δ[O(2)Hb]), deoxy- (Δ[HHb]) and total hemoglobin (Δ[tHb]), and tissue saturation index (TSI). NIRS inflection points (NIP), reflecting changes in tissue-specific oxygenation, were determined and their coincidence with ventilatory thresholds [anaerobic threshold (AT), respiratory compensation point (RC); V-slope method] was examined. Blood O(2) carrying capacity [total hemoglobin mass (tHb-mass)] was determined with the CO-rebreathing method. In all tissues, NIPs coincided with AT, whereas RC was followed by NIPs. High tHb-mass associated with leg muscle deoxygenation at peak exercise (e.g., Δ[HHb] from baseline walking to peak exercise vs. tHb-mass: r = 0.64, p < 0.01), but not with arm muscle- or cerebral deoxygenation. In conclusion, regional tissue oxygenation was characterized by inflection points, and tissue oxygenation in relation to alveolar gas exchange during incremental treadmill exercise resembled previous findings made during incremental cycling. It was also found out, that O(2) delivery to less active m. biceps brachii may be limited by an accelerated increase in ventilation at high running intensities. In addition, high capacity for blood O(2) carrying was associated with a high level of m. vastus lateralis deoxygenation at peak exercise. fi
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Frontiers in Physiology
dc.rights en
dc.subject 315 Sport and fitness sciences en
dc.subject 3121 Internal medicine en
dc.subject Kliininen fysiologia en
dc.subject Liikuntalääketiede en
dc.title Alveolar gas exchange and tissue oxygenation during incremental treadmill exercise, and their associations with blood O(2) carrying capacity en
dc.type Article
dc.description.version Peer reviewed
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
dc.contributor.pbl

Files in this item

Total number of downloads: Loading...

Files Size Format View
fphys_03_00265.pdf 1.170Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record