Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

Show full item record



Permalink

http://hdl.handle.net/10138/167038

Citation

Jarvis , D , Mitchell , J S , Law , P J , Palin , K , Tuupanen , S , Gylfe , A , Hanninen , U A , Cajuso , T , Tanskanen , T , Kondelin , J , Kaasinen , E , Sarin , A-P , Kaprio , J , Eriksson , J G , Rissanen , H , Knekt , P , Pukkala , E , Jousilahti , P , Salomaa , V , Ripatti , S , Palotie , A , Järvinen , H , Renkonen-Sinisalo , L , Lepistö , A , Bohm , J , Mecklin , J-P , Al-Tassan , N A , Palles , C , Martin , L , Barclay , E , Farrington , S M , Timofeeva , M N , Meyer , B F , Wakil , S M , Campbell , H , Smith , C G , Idziaszczyk , S , Maughan , T S , Kaplan , R , Kerr , R , Kerr , D , Buchanan , D D , Win , A K , Hopper , J L , Jenkins , M A , Lindor , N M , Newcomb , P A , Gallinger , S , Conti , D , Schumacher , F , Casey , G , Taipale , J , Aaltonen , L A , Cheadle , J P , Dunlop , M G , Tomlinson , I P & Houlston , R S 2016 , ' Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer ' , British Journal of Cancer , vol. 115 , no. 2 , pp. 266-272 . https://doi.org/10.1038/bjc.2016.188

Title: Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer
Author: Jarvis, David; Mitchell, Jonathan S.; Law, Philip J.; Palin, Kimmo; Tuupanen, Sari; Gylfe, Alexandra; Hanninen, Ulrika A.; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Kaprio, Jaakko; Eriksson, Johan G.; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Järvinen, Heikki; Renkonen-Sinisalo, Laura; Lepistö, Anna; Bohm, Jan; Mecklin, Jukka-Pekka; Al-Tassan, Nada A.; Palles, Claire; Martin, Lynn; Barclay, Ella; Farrington, Susan M.; Timofeeva, Maria N.; Meyer, Brian F.; Wakil, Salma M.; Campbell, Harry; Smith, Christopher G.; Idziaszczyk, Shelley; Maughan, Timothy S.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Buchanan, Daniel D.; Win, Aung K.; Hopper, John L.; Jenkins, Mark A.; Lindor, Noralane M.; Newcomb, Polly A.; Gallinger, Steve; Conti, David; Schumacher, Fred; Casey, Graham; Taipale, Jussi; Aaltonen, Lauri A.; Cheadle, Jeremy P.; Dunlop, Malcolm G.; Tomlinson, Ian P.; Houlston, Richard S.
Contributor organization: Research Programs Unit
Lauri Antti Aaltonen / Principal Investigator
Genome-Scale Biology (GSB) Research Program
Medicum
Department of Medical and Clinical Genetics
Institute for Molecular Medicine Finland
Clinicum
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Samuli Olli Ripatti / Principal Investigator
Aarno Palotie / Principal Investigator
Heikki Järvinen / Principal Investigator
Department of Surgery
II kirurgian klinikka
Jussi Taipale / Principal Investigator
Biostatistics Helsinki
Complex Disease Genetics
Genomics of Neurological and Neuropsychiatric Disorders
Genetic Epidemiology
Date: 2016-07-12
Language: eng
Number of pages: 7
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
DOI: https://doi.org/10.1038/bjc.2016.188
URI: http://hdl.handle.net/10138/167038
Abstract: Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC. Methods: We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC cases and 18 386 controls. Results: In the MR analysis, the odds ratios (ORs) of CRC risk per unit increase in BMI, WHR and childhood obesity were 1.23 (95% CI: 1.02-1.49, P = 0.033), 1.59 (95% CI: 1.08-2.34, P = 0.019) and 1.07 (95% CI: 1.03-1.13, P = 0.018), respectively. There was no evidence for association between birth weight and CRC (OR = 1.22, 95% CI: 0.89-1.67, P = 0.22). Combining these data with a concurrent MR-based analysis for BMI and WHR with CRC risk (totalling to 18 190 cases, 27 617 controls) provided increased support, ORs for BMI and WHR were 1.26 (95% CI: 1.10-1.44, P = 7.7 x 10(-4)) and 1.40 (95% CI: 1.14-1.72, P = 1.2 x 10(-3)), respectively. Conclusions: These data provide further evidence for a strong causal relationship between adiposity and the risk of developing CRC highlighting the urgent need for prevention and treatment of adiposity.
Subject: Mendelian randomisation
adiposity
colorectal cancer
BODY-MASS INDEX
OBESITY
METAANALYSIS
EPIDEMIOLOGY
INSTRUMENTS
WEIGHT
COMMON
3122 Cancers
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
bjc2016188a.pdf 390.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record