An RGS2 3 ' UTR polymorphism is associated with preeclampsia in overweight women

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Karppanen , T , Kaartokallio , T , Klemetti , M M , Heinonen , S , Kajantie , E , Kere , J , Kivinen , K , Pouta , A , Staff , A C & Laivuori , H 2016 , ' An RGS2 3 ' UTR polymorphism is associated with preeclampsia in overweight women ' , BMC Genetics , vol. 17 , 121 .

Title: An RGS2 3 ' UTR polymorphism is associated with preeclampsia in overweight women
Author: Karppanen, Tiina; Kaartokallio, Tea; Klemetti, Miira M.; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Staff, Anne Cathrine; Laivuori, Hannele
Contributor organization: Medicum
Pregnancy and Genes
Department of Medical and Clinical Genetics
Department of Obstetrics and Gynecology
Children's Hospital
Lastentautien yksikkö
University of Helsinki
Juha Kere / Principal Investigator
Institute for Molecular Medicine Finland
HUS Gynecology and Obstetrics
Date: 2016-08-24
Language: eng
Number of pages: 7
Belongs to series: BMC Genetics
ISSN: 1471-2156
Abstract: Background: Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3'UTR polymorphism of the Regulator of G-protein signaling 2 gene (RGS2) in the mother has been implicated in preeclampsia as well as in the development of chronic hypertension after preeclampsia. The RGS2 protein acts as an inhibitor of physiological vasoconstrictive pathways, and a low RGS2 level is associated with hypertension and obesity, two conditions that predispose to preeclampsia. We genotyped the rs4606 polymorphism in 1339 preeclamptic patients and in 697 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort to study the association of the variant with preeclampsia. Results: No association between rs4606 and preeclampsia was detected in the analysis including all women. However, the polymorphism was associated with preeclampsia in a subgroup of overweight women (body mass index >= 25 kg/m(2), and <30 kg/m(2)) (dominant model; odds ratio, 1.64; 95 % confidence interval, 1.10-2.42). Conclusions: Our results suggest that RGS2 might be involved in the pathogenesis of preeclampsia particularly in overweight women and contribute to their increased risk for hypertension and other types of cardiovascular disease later in life.
Subject: Preeclampsia
Regulator of G-protein signaling 2
Candidate gene study
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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