Systematic review of loperamide : No proof of antibiotics being superior to loperamide in treatment of mild/moderate travellers' diarrhoea

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Laaveri , T , Sterne , J , Rombo , L & Kantele , A 2016 , ' Systematic review of loperamide : No proof of antibiotics being superior to loperamide in treatment of mild/moderate travellers' diarrhoea ' , Travel medicine and infectious disease , vol. 14 , no. 4 , pp. 299-312 . https://doi.org/10.1016/j.tmaid.2016.06.006

Title: Systematic review of loperamide : No proof of antibiotics being superior to loperamide in treatment of mild/moderate travellers' diarrhoea
Author: Laaveri, Tinja; Sterne, Jesper; Rombo, Lars; Kantele, Anu
Other contributor: University of Helsinki, Department of Medicine
University of Helsinki, Clinicum



Date: 2016
Language: eng
Number of pages: 14
Belongs to series: Travel medicine and infectious disease
ISSN: 1477-8939
DOI: https://doi.org/10.1016/j.tmaid.2016.06.006
URI: http://hdl.handle.net/10138/167666
Abstract: Looking at the worldwide emergency of antimicrobial resistance, international travellers appear to have a central role in spreading the bacteria across the globe. Travellers' diarrhoea (TD) is the most common disease encountered by visitors to the (sub) tropics. Both TD and its treatment with antibiotics have proved significant independent risk factors of colonization by resistant intestinal bacteria while travelling. Travellers should therefore be given preventive advice regarding TD and cautioned about taking antibiotics: mild or moderate TD does not require antibiotics. Logical alternatives are medications with effects on gastrointestinal function, such as loperamide. The present review explores literature on loperamide in treating TD. Adhering to manufacturer's dosage recommendations, loperamide offers a safe and effective alternative for relieving mild and moderate symptoms. Moreover, loperamide taken singly does no predispose to contracting MDR bacteria. Most importantly, we found no proof that would show antibiotics to be significantly more effective than loperamide in treating mild/moderate TD. (C) 2016 The Authors. Published by Elsevier Ltd.
Subject: Adverse drug event
Safety
Antibiotics
Antidiarrhoeals
Antibiotic resistance
IRRITABLE-BOWEL-SYNDROME
LACTAMASE-PRODUCING ENTEROBACTERIACEAE
CLOSTRIDIUM-DIFFICILE INFECTION
RESOURCE-LIMITED DESTINATIONS
US MILITARY PERSONNEL
TOXIC MEGACOLON
ANTIMICROBIAL RESISTANCE
ACUTE-PANCREATITIS
PLUS LOPERAMIDE
RISK-FACTORS
3142 Public health care science, environmental and occupational health
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