Influence of Ethnicity on the Accuracy of Non-Invasive Scores Predicting Non-Alcoholic Fatty Liver Disease

Show full item record



Permalink

http://hdl.handle.net/10138/167704

Citation

Xia , M-F , Yki-Jarvinen , H , Bian , H , Lin , H-D , Yan , H-M , Chang , X-X , Zhou , Y & Gao , X 2016 , ' Influence of Ethnicity on the Accuracy of Non-Invasive Scores Predicting Non-Alcoholic Fatty Liver Disease ' , PLoS One , vol. 11 , no. 8 , 0160526 . https://doi.org/10.1371/journal.pone.0160526

Title: Influence of Ethnicity on the Accuracy of Non-Invasive Scores Predicting Non-Alcoholic Fatty Liver Disease
Author: Xia, Ming-Feng; Yki-Jarvinen, Hannele; Bian, Hua; Lin, Huan-Dong; Yan, Hong-Mei; Chang, Xin-Xia; Zhou, You; Gao, Xin
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2016-08-31
Language: eng
Number of pages: 12
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/167704
Abstract: Objectives Presence of non-alcoholic fatty liver disease (NAFLD) can predict risks for diabetes, cardiovascular disease and advanced liver disease in the general population. We aimed to establish a non-invasive score for prediction of NAFLD in Han Chinese, the largest ethnic group in the world, and detect whether ethnicity influences the accuracy of such a score. Methods Liver fat content (LFAT) was measured by quantitative ultrasound in 3548 subjects in the Shanghai Changfeng Community and a Chinese score was created using multivariate logistic regression analyses. This new score was internally validated in Chinese and externally in Finns. Its diagnostic performance was compared to the NAFLD liver fat score, fatty liver index (FLI) and hepatic steatosis index (HSI) developed in Finns, Italians and Koreans. We also analyzed how obesity related to LFAT measured by H-1-MRS in 79 Finns and 118 Chinese with type 2 diabetes (T2D). Results The metabolic syndrome and T2D, fasting serum insulin, body mass index (BMI) and AST/ALT ratio were independent predictors of NAFLD in Chinese. The AUROC in the Chinese validation cohort was 0.76 (0.73-0.78) and in Finns 0.73 (0.68-0.78) (p Conclusion The predictors of NAFLD in Han Chinese are as in Europids but the Chinese have more LFAT for any given degree of obesity than Europids. Ethnicity needs to be considered when NAFLD is predicted using risk scores.
Subject: CIRCULATING TRIACYLGLYCEROL SIGNATURES
HEPATIC STEATOSIS
CONFERS SUSCEPTIBILITY
CARDIOVASCULAR-DISEASE
METABOLIC-DISORDERS
MAGNETIC-RESONANCE
GENERAL-POPULATION
I148M VARIANT
MANAGEMENT
PNPLA3
3121 Internal medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
asset.pdf 886.2Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record