Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers

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Huovinen , V , Bucci , M , Lipponen , H , Kiviranta , R , Sandboge , S , Raiko , J , Koskinen , S , Koskensalo , K , Eriksson , J G , Parkkola , R , Iozzo , P & Nuutila , P 2016 , ' Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers ' , PLoS One , vol. 11 , no. 9 , 0163723 . https://doi.org/10.1371/journal.pone.0163723

Title: Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers
Author: Huovinen, Ville; Bucci, Marco; Lipponen, Heta; Kiviranta, Riku; Sandboge, Samuel; Raiko, Juho; Koskinen, Suvi; Koskensalo, Kalle; Eriksson, Johan G.; Parkkola, Riitta; Iozzo, Patricia; Nuutila, Pirjo
Contributor organization: Clinicum
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Date: 2016-09-26
Language: eng
Number of pages: 14
Belongs to series: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0163723
URI: http://hdl.handle.net/10138/167999
Abstract: Bone marrow insulin sensitivity may be an important factor for bone health in addition to bone mineral density especially in insulin resistant conditions. First we aimed to study if prenatal maternal obesity plays a role in determining bone marrow insulin sensitivity in elderly female offspring. Secondly we studied if a four-month individualized resistance training intervention increases bone marrow insulin sensitivity in elderly female offspring and whether this possible positive outcome is regulated by the offspring's mother's obesity status. 37 frail elderly females (mean age 71.9 +/- 3.1 years) of which 20 were offspring of lean/normal-weight mothers (OLM, maternal BMI = 28.1 kg/m(2)) were studied before and after a four-month individualized resistance training intervention. Nine age-and sex-matched non-frail controls (maternal BMI
Subject: ADIPOSE-TISSUE
SKELETAL-MUSCLE
GLUCOSE-UPTAKE
MATERNAL OBESITY
MINERAL DENSITY
MR SPECTROSCOPY
OLDER-ADULTS
FAT-CONTENT
IN-VIVO
SECRETION
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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