Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form

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Boggavarapu , N R , Lalitkumar , S , Joshua , V , Kasvandik , S , Salumets , A , Lalitkumar , P G & Gemzell-Danielsson , K 2016 , ' Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form ' , Scientific Reports , vol. 6 , 33811 . https://doi.org/10.1038/srep33811

Title: Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form
Author: Boggavarapu, Nageswara Rao; Lalitkumar, Sujata; Joshua, Vijay; Kasvandik, Sergo; Salumets, Andres; Lalitkumar, Parameswaran Grace; Gemzell-Danielsson, Kristina
Contributor: University of Helsinki, Clinicum
Date: 2016-09-26
Language: eng
Number of pages: 13
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/168001
Abstract: The complexity of endometrial receptivity at the molecular level needs to be explored in detail to improve the management of infertility. Here, differential expression of transcriptomes in receptive endometrial glands and stroma revealed Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a progesterone regulated factor and confirmed by various methods, both at mRNA and protein level. The involvement of ENPP3 in embryo attachment was tested in an in vitro model for human embryo implantation. Interestingly, there was high expression of ENPP3 mRNA in stroma but not protein. Presence of N-glycosylated ENPP3 in receptive phase uterine fluid in women confirms its regulation by progesterone and makes it possible to use in a non-invasive test of endometrial receptivity.
Subject: GENE-EXPRESSION
MENSTRUAL-CYCLE
IN-VITRO
IMPLANTATION
MIFEPRISTONE
LOCALIZATION
INTEGRINS
WINDOW
WOMEN
3123 Gynaecology and paediatrics
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