Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity

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Salmela , E , Renvall , H , Kujala , J , Hakosalo , O , Illman , M , Vihla , M , Leinonen , E , Salmelin , R & Kere , J 2016 , ' Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity ' , European Journal of Neuroscience , vol. 44 , no. 3 , pp. 1963-1971 . https://doi.org/10.1111/ejn.13300

Title: Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity
Author: Salmela, Elina; Renvall, Hanna; Kujala, Jan; Hakosalo, Osmo; Illman, Mia; Vihla, Minna; Leinonen, Eira; Salmelin, Riitta; Kere, Juha
Contributor: University of Helsinki, Research Programme for Molecular Neurology
University of Helsinki, Neurologian yksikkö
University of Helsinki, Research Programme for Molecular Neurology
University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
Date: 2016-08
Language: eng
Number of pages: 9
Belongs to series: European Journal of Neuroscience
ISSN: 0953-816X
URI: http://hdl.handle.net/10138/168014
Abstract: Several functional and morphological brain measures are partly under genetic control. The identification of direct links between neuroimaging signals and corresponding genetic factors can reveal cellular-level mechanisms behind the measured macroscopic signals and contribute to the use of imaging signals as probes of genetic function. To uncover possible genetic determinants of the most prominent brain signal oscillation, the parieto-occipital 10-Hz alpha rhythm, we measured spontaneous brain activity with magnetoencephalography in 210 healthy siblings while the subjects were resting, with eyes closed and open. The reactivity of the alpha rhythm was quantified from the difference spectra between the two conditions. We focused on three measures: peak frequency, peak amplitude and the width of the main spectral peak. In accordance with earlier electroencephalography studies, spectral peak amplitude was highly heritable (h(2)>0.75). Variance component-based analysis of 28000 single-nucleotide polymorphism markers revealed linkage for both the width and the amplitude of the spectral peak. The strongest linkage was detected for the width of the spectral peak over the left parieto-occipital cortex on chromosome 10 (LOD=2.814, nominal P
Subject: alpha rhythm
heritability
linkage study
magnetoencephalography
WHOLE-GENOME ASSOCIATION
SEROTONIN RECEPTOR 7
ALPHA OSCILLATIONS
WORKING-MEMORY
NEURONAL MORPHOLOGY
MOLECULAR-CLONING
WIDE ASSOCIATION
SCHIZOPHRENIA
LINKAGE
EEG
3112 Neurosciences
3124 Neurology and psychiatry
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