Physical activity and dementia : Long-term follow-up study of adult twins

Show full item record



Permalink

http://hdl.handle.net/10138/168349

Citation

Iso-Markku , P , Waller , K , Kujala , U M & Kaprio , J 2015 , ' Physical activity and dementia : Long-term follow-up study of adult twins ' , Annals of Medicine , vol. 47 , no. 2 , pp. 81-87 . https://doi.org/10.3109/07853890.2014.994675

Title: Physical activity and dementia : Long-term follow-up study of adult twins
Author: Iso-Markku, Paula; Waller, Katja; Kujala, Urho M.; Kaprio, Jaakko
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2015-03
Language: eng
Number of pages: 7
Belongs to series: Annals of Medicine
ISSN: 0785-3890
URI: http://hdl.handle.net/10138/168349
Abstract: Introduction. Physical activity is associated with a decreased occurrence of dementia. In twins, we investigated the effect of persistent physical activity in adulthood on mortality due to dementia. Materials and methods. Physical activity was queried in 1975 and 1981 from the members of the older Finnish Twin Cohort (n = 2 1,791), who were aged 24-60 years at the end of 1981. The subjects were divided into three categories according to the persistence of their vigorous physical activity. Dementia deaths were followed up to the end of 2011. Results. During the 29-year follow-up, 353 subjects died of dementia. In individual-based analyses the age-and sex-adjusted hazard ratio (HR) was 0.65 (95% CI 0.43-0.98) for subjects partaking in vigorous physical activities in both 1975 and 1981 compared to those who were inactive in both years. No significant change was observed after adjusting for potential confounding factors. The corresponding HR for within-pair comparisons of the less active twin versus the more active co-twin was 0.48 (95% CI 0.17-1.32). The results for analyses of the volume of physical activity were inconclusive. Conclusions. Persistent vigorous leisure-time physical activity protects from dementia, and the effect appears to remain after taking into account childhood environment.
Subject: Cognition
cognitive decline
dementia
exercise
physical activity
twins
VASCULAR RISK-FACTORS
ALZHEIMERS-DISEASE
COGNITIVE IMPAIRMENT
DECADES LATER
OLDER-ADULTS
ACADEMIC-ACHIEVEMENT
WAIST CIRCUMFERENCE
INCIDENT DEMENTIA
ELDERLY PERSONS
MIDLIFE
3142 Public health care science, environmental and occupational health
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Main_ArticleRevisedTUHAT.docx 59.45Kb Microsoft Word View/Open
Physical_activity_and_dementia.pdf 445.2Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record