Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?

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Taskinen , M-R & Boren , J 2016 , ' Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease? ' , Current atherosclerosis reports. , vol. 18 , no. 10 , 59 . https://doi.org/10.1007/s11883-016-0614-1

Title: Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?
Author: Taskinen, Marja-Riitta; Boren, Jan
Contributor: University of Helsinki, Research Programs Unit
Date: 2016-10
Language: eng
Number of pages: 8
Belongs to series: Current atherosclerosis reports.
ISSN: 1523-3804
URI: http://hdl.handle.net/10138/168421
Abstract: ApoC-III was discovered almost 50 years ago, but for many years, it did not attract much attention. However, as epidemiological and Mendelian randomization studies have associated apoC-III with low levels of triglycerides and decreased incidence of cardiovascular disease (CVD), it has emerged as a novel and potentially powerful therapeutic approach to managing dyslipidemia and CVD risk. The atherogenicity of apoC-III has been attributed to both direct lipoprotein lipase-mediated mechanisms and indirect mechanisms, such as promoting secretion of triglyceride-rich lipoproteins (TRLs), provoking proinflammatory responses in vascular cells and impairing LPL-independent hepatic clearance of TRL remnants. Encouraging results from clinical trials using antisense oligonucleotide, which selectively inhibits apoC-III, indicate that modulating apoC-III may be a potent therapeutic approach to managing dyslipidemia and cardiovascular disease risk.
Subject: apoC-III
Lipoproteins
Triglycerides
Remnants
CVD
LOW-DENSITY LIPOPROTEINS
TRIGLYCERIDE-RICH LIPOPROTEINS
OF-FUNCTION MUTATIONS
B-CONTAINING LIPOPROTEINS
ELEMENT-BINDING PROTEIN
CORONARY-HEART-DISEASE
C-III
RISK-FACTOR
APO-B
ATHEROGENIC LIPOPROTEINS
3121 General medicine, internal medicine and other clinical medicine
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