Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb

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http://hdl.handle.net/10138/168619

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Christiano Quaresma , A J , Bugai , A & Barboric , M 2016 , ' Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb ' , Nucleic Acids Research , vol. 44 , no. 16 , pp. 7527-7539 . https://doi.org/10.1093/nar/gkw585

Title: Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb
Author: Christiano Quaresma, Alexandre Jose; Bugai, Andrii; Barboric, Matjaz
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Medicum
Date: 2016-09-19
Language: eng
Number of pages: 13
Belongs to series: Nucleic Acids Research
ISSN: 0305-1048
URI: http://hdl.handle.net/10138/168619
Abstract: Release of RNA polymerase II (Pol II) from promoter-proximal pausing has emerged as a critical step regulating gene expression in multicellular organisms. The transition of Pol II into productive elongation requires the kinase activity of positive transcription elongation factor b (P-TEFb), which is itself under a stringent control by the inhibitory 7SK small nuclear ribonucleoprotein (7SK snRNP) complex. Here, we provide an overview on stimulating Pol II pause release by P-TEFb and on sequestering P-TEFb into 7SK snRNP. Furthermore, we highlight mechanisms that govern anchoring of 7SK snRNP to chromatin as well as means that release P-TEFb from the inhibitory complex, and propose a unifying model of P-TEFb activation on chromatin. Collectively, these studies shine a spotlight on the central role of RNA binding proteins (RBPs) in directing the inhibition and activation of P-TEFb, providing a compelling paradigm for controlling Pol II transcription with a non-coding RNA.
Subject: PRE-MESSENGER-RNA
SMALL NUCLEAR-RNA
DEPENDENT TRANSCRIPTIONAL ELONGATION
RECOGNITION PARTICLE RNA
BROMODOMAIN PROTEIN BRD4
T-BINDING DOMAIN
HIV-1 TAT
POSITIVE TRANSCRIPTION
PAUSE RELEASE
FACTOR-B
1182 Biochemistry, cell and molecular biology
3111 Biomedicine
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