Association of Matrix Metalloproteinases-7,-8 and-9 and TIMP-1 with Disease Severity in Acute Pancreatitis. A Cohort Study

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Nukarinen , E , Lindstrom , O , Kuuliala , K , Kylänpää , L , Pettilä , V , Puolakkainen , P , Kuuliala , A , Hamalainen , M , Moilanen , E , Repo , H & Hästbacka , J 2016 , ' Association of Matrix Metalloproteinases-7,-8 and-9 and TIMP-1 with Disease Severity in Acute Pancreatitis. A Cohort Study ' , PLoS One , vol. 11 , no. 8 , 0161480 . https://doi.org/10.1371/journal.pone.0161480

Title: Association of Matrix Metalloproteinases-7,-8 and-9 and TIMP-1 with Disease Severity in Acute Pancreatitis. A Cohort Study
Author: Nukarinen, Eija; Lindstrom, Outi; Kuuliala, Krista; Kylänpää, Leena; Pettilä, Ville; Puolakkainen, Pauli; Kuuliala, Antti; Hamalainen, Mari; Moilanen, Eeva; Repo, Heikki; Hästbacka, Johanna
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Surgery
University of Helsinki, Medicum
University of Helsinki, Department of Surgery
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2016-08-25
Language: eng
Number of pages: 11
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/168666
Abstract: Objectives Several biomarkers for early detection of severe acute pancreatitis (SAP) have been presented. Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are released early in inflammation. We aimed to assess levels of MMP-7, -8, -9 and TIMP-1 in acute pancreatitis (AP) and explore their ability to detect disease severity. Our second aim was to find an association between MMPs, TIMP and creatinine. Methods We collected plasma samples for MMP-7, -8, -9 and TIMP-1 analyses from 176 patients presenting within 96 h from onset of acute pancreatitis (AP) symptoms. We used samples from 32 control subjects as comparison. The revised Atlanta Classification was utilised to assess severity of disease. Receiver operating characteristic curve analysis and Spearman's Rho-test were utilised for statistical calculations. Results Compared with controls, patients showed higher levels of all studied markers. MMP-8 was higher in moderately severe AP than in mild AP (p = 0.005) and MMP-8, -9 and TIMP-1 were higher in severe than in mild AP (p
Subject: ACUTE KIDNEY INJURY
PREDICTING SEVERITY
TISSUE INHIBITOR
SERUM CREATININE
MATRIX-METALLOPROTEINASE-9
PROGRESSION
MARKERS
INFLAMMATION
COLLAGENASE
EXPRESSION
3121 General medicine, internal medicine and other clinical medicine
3126 Surgery, anesthesiology, intensive care, radiology
3111 Biomedicine
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