Paving the way of systems biology and precision medicine in allergic diseases : the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015

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Bousquet , J , Anto , J M , Akdis , M , Auffray , C , Keil , T , Momas , I , Postma , D S , Valenta , R , Wickman , M , Cambon-Thomsen , A , Haahtela , T , Lambrecht , B N , Carlsen , K C L , Koppelman , G H , Sunyer , J , Zuberbier , T , Annesi-Maesano , I , Arno , A , Bindslev-Jensen , C , De Carlo , G , Forastiere , F , Heinrich , J , Kowalski , M L , Maier , D , Melen , E , Palkonen , S , Smit , H A , Standl , M , Wright , J , Asarnoj , A , Benet , M , Ballardini , N , Garcia-Aymerich , J , Gehring , U , Guerra , S , Hohman , C , Kull , I , Lupinek , C , Pinart , M , Skrindo , I , Westman , M , Smagghe , D , Akdis , C , Albang , R , Anastasova , V , Anderson , N , Bachert , C , Ballereau , S , Ballester , F , Basagana , X , Bedbrook , A , Bergstrom , A , von Berg , A , Brunekreef , B , Burte , E , Carlsen , K H , Chatzi , L , Coquet , J M , Curin , M , Demoly , P , Eller , E , Fantini , M P , Gerhard , B , Hammad , H , von Hertzen , L , Hovland , V , Jacquemin , B , Just , J , Keller , T , Kerkhof , M , Kiss , R , Kogevinas , M , Koletzko , S , Lau , S , Lehmann , I , Lemonnier , N , McEachan , R , Mäkelä , M , Mestres , J , Minina , E , Mowinckel , P , Nadif , R , Nawijn , M , Oddie , S , Pellet , J , Pin , I , Porta , D , Ranciere , F , Rial-Sebbag , A , Saeys , Y , Schuijs , M J , Siroux , V , Tischer , C G , Torrent , M , Varraso , R , De Vocht , J , Wenger , K , Wieser , S & Xu , C 2016 , ' Paving the way of systems biology and precision medicine in allergic diseases : the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015 ' , Allergy : European journal of allergy and clinical immunology , vol. 71 , no. 11 , pp. 1513-1525 . https://doi.org/10.1111/all.12880

Title: Paving the way of systems biology and precision medicine in allergic diseases : the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015
Author: Bousquet, J.; Anto, J. M.; Akdis, M.; Auffray, C.; Keil, T.; Momas, I.; Postma, D. S.; Valenta, R.; Wickman, M.; Cambon-Thomsen, A.; Haahtela, T.; Lambrecht, B. N.; Carlsen, K. C. Lodrup; Koppelman, G. H.; Sunyer, J.; Zuberbier, T.; Annesi-Maesano, I.; Arno, A.; Bindslev-Jensen, C.; De Carlo, G.; Forastiere, F.; Heinrich, J.; Kowalski, M. L.; Maier, D.; Melen, E.; Palkonen, S.; Smit, H. A.; Standl, M.; Wright, J.; Asarnoj, A.; Benet, M.; Ballardini, N.; Garcia-Aymerich, J.; Gehring, U.; Guerra, S.; Hohman, C.; Kull, I.; Lupinek, C.; Pinart, M.; Skrindo, I.; Westman, M.; Smagghe, D.; Akdis, C.; Albang, R.; Anastasova, V.; Anderson, N.; Bachert, C.; Ballereau, S.; Ballester, F.; Basagana, X.; Bedbrook, A.; Bergstrom, A.; von Berg, A.; Brunekreef, B.; Burte, E.; Carlsen, K. H.; Chatzi, L.; Coquet, J. M.; Curin, M.; Demoly, P.; Eller, E.; Fantini, M. P.; Gerhard, B.; Hammad, H.; von Hertzen, L.; Hovland, V.; Jacquemin, B.; Just, J.; Keller, T.; Kerkhof, M.; Kiss, R.; Kogevinas, M.; Koletzko, S.; Lau, S.; Lehmann, I.; Lemonnier, N.; McEachan, R.; Mäkelä, M.; Mestres, J.; Minina, E.; Mowinckel, P.; Nadif, R.; Nawijn, M.; Oddie, S.; Pellet, J.; Pin, I.; Porta, D.; Ranciere, F.; Rial-Sebbag, A.; Saeys, Y.; Schuijs, M. J.; Siroux, V.; Tischer, C. G.; Torrent, M.; Varraso, R.; De Vocht, J.; Wenger, K.; Wieser, S.; Xu, C.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Clinicum
Date: 2016-11
Language: eng
Number of pages: 13
Belongs to series: Allergy : European journal of allergy and clinical immunology
ISSN: 0105-4538
URI: http://hdl.handle.net/10138/169268
Abstract: MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.
Subject: asthma
IgE
multimorbidity
polysensitization
rhinitis
CHRONIC RESPIRATORY-DISEASES
EUROPEAN INNOVATION PARTNERSHIP
BIRTH COHORT
CHILDHOOD ASTHMA
ATOPIC-DERMATITIS
IMMUNOLOGICAL REACTIVITY
IGE SENSITIZATION
IMMUNE-RESPONSES
IMMUNOGLOBULIN-E
INTEGRATED CARE
3121 General medicine, internal medicine and other clinical medicine
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