Genome-Wide Meta-Analysis of Sciatica in Finnish Population

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http://hdl.handle.net/10138/169273

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Lemmelä , S , Solovieva , S , Shiri , R , Benner , C , Heliovaara , M , Kettunen , J , Anttila , V , Ripatti , S , Perola , M , Seppala , I , Juonala , M , Kahonen , M , Salomaa , V , Viikari , J , Raitakari , O T , Lehtimaki , T , Palotie , A , Viikari-Juntura , E & Husgafvel-Pursiainen , K 2016 , ' Genome-Wide Meta-Analysis of Sciatica in Finnish Population ' , PLoS One , vol. 11 , no. 10 , 0163877 . https://doi.org/10.1371/journal.pone.0163877

Title: Genome-Wide Meta-Analysis of Sciatica in Finnish Population
Author: Lemmelä, Susanna; Solovieva, Svetlana; Shiri, Rahman; Benner, Christian; Heliovaara, Markku; Kettunen, Johannes; Anttila, Verneri; Ripatti, Samuli; Perola, Markus; Seppala, Ilkka; Juonala, Markus; Kahonen, Mika; Salomaa, Veikko; Viikari, Jorma; Raitakari, Olli T.; Lehtimaki, Terho; Palotie, Aarno; Viikari-Juntura, Eira; Husgafvel-Pursiainen, Kirsti
Contributor: University of Helsinki, Genomics of Neurological and Neuropsychiatric Disorders
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2016-10-20
Language: eng
Number of pages: 18
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/169273
Abstract: Sciatica or the sciatic syndrome is a common and often disabling low back disorder in the working-age population. It has a relatively high heritability but poorly understood molecular mechanisms. The Finnish population is a genetic isolate where small founder population and bottleneck events have led to enrichment of certain rare and low frequency variants. We performed here the first genome-wide association (GWAS) and meta-analysis of sciatica. The meta-analysis was conducted across two GWAS covering 291 Finnish sciatica cases and 3671 controls genotyped and imputed at 7.7 million autosomal variants. The most promising loci (p
Subject: LOW-BACK-PAIN
LUMBAR DISC DEGENERATION
NUCLEAR FACTOR-I
CLASS II/III REGION
MYOSIN-V FUNCTION
KNEE OSTEOARTHRITIS
ASSOCIATION
GENE
DISEASE
TRANSCRIPTION
3142 Public health care science, environmental and occupational health
3111 Biomedicine
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