Soluble CD73 in Critically Ill Septic Patients Data from the Prospective FINNAKI Study

Show full item record



Permalink

http://hdl.handle.net/10138/169319

Citation

Vaara , S T , Hollmen , M , Korhonen , A-M , Maksimow , M , Ala-Kokko , T , Salmi , M , Jalkanen , S , Pettilä , V & FINNAKI Study Grp 2016 , ' Soluble CD73 in Critically Ill Septic Patients Data from the Prospective FINNAKI Study ' PLoS One , vol. 11 , no. 10 , 0164420 . DOI: 10.1371/journal.pone.0164420

Title: Soluble CD73 in Critically Ill Septic Patients Data from the Prospective FINNAKI Study
Author: Vaara, Suvi T.; Hollmen, Maija; Korhonen, Anna-Maija; Maksimow, Mikael; Ala-Kokko, Tero; Salmi, Marko; Jalkanen, Sirpa; Pettilä, Ville; FINNAKI Study Grp
Contributor: University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of Diagnostics and Therapeutics
Date: 2016-10-12
Language: eng
Number of pages: 14
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/169319
Abstract: Background CD73 dephosphorylates adenosine monophosphate to adenosine that is an anti-inflammatory molecule inhibiting immune activation and vascular leakage. Therefore, CD73 could be an interesting mediator both in sepsis and acute kidney injury (AKI). We aimed to explore the soluble CD73 (sCD73) levels and their evolution in critically ill patients with severe sepsis and, second, to scrutinize the potential association of sCD73 levels with AKI and 90-day mortality. Methods This was a post-hoc laboratory analysis of the prospective, observational FINNAKI study conducted in 17 Finnish ICU during 5 months in 2011-2012. Plasma samples of 588 patients admitted with severe sepsis/shock or with developing severe sepsis were analyzed at 0h (ICU admission) and 24h, and additionally, on day 3 or day 5 from a subset of the patients. Results The median [IQR] sCD73 levels at 0h were 5.11 [3.29-8.28] ng/mL and they decreased significantly from 0h to 4.14 [2.88-7.11] ng/mL at 24h, P Conclusions Compared to normal population, the sCD73 levels were generally low at 0h, showed a decrease to 24h, and later an increase by day 5. The sCD73 levels do not seem useful in predicting the development of AKI or 90-day mortality among patients with severe sepsis or shock.
Subject: ACUTE KIDNEY INJURY
INTENSIVE-CARE UNITS
SEVERE SEPSIS
ECTO-5'-NUCLEOTIDASE CD73
ORGAN FAILURE
MORTALITY
SHOCK
3121 Internal medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
file.pdf 1.357Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record