Increased Oxidative Stress in the Proximal Stomach of Patients with Barrett's Esophagus and Adenocarcinoma of the Esophagus and Esophagogastric Junction

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dc.contributor.author Kauppi, Juha
dc.contributor.author Räsänen, Jari
dc.contributor.author Sihvo, Eero
dc.contributor.author Nieminen, Urpo
dc.contributor.author Arkkila, Perttu
dc.contributor.author Ahotupa, Markku
dc.contributor.author Salo, Jarmo
dc.date.accessioned 2016-11-29T10:47:02Z
dc.date.available 2016-11-29T10:47:02Z
dc.date.issued 2016-08
dc.identifier.citation Kauppi , J , Räsänen , J , Sihvo , E , Nieminen , U , Arkkila , P , Ahotupa , M & Salo , J 2016 , ' Increased Oxidative Stress in the Proximal Stomach of Patients with Barrett's Esophagus and Adenocarcinoma of the Esophagus and Esophagogastric Junction ' , Translational oncology , vol. 9 , no. 4 , pp. 336-339 . https://doi.org/10.1016/j.tranon.2016.06.004
dc.identifier.other PURE: 72240972
dc.identifier.other PURE UUID: c0b68755-5b8d-4144-ad99-c6001ba0e270
dc.identifier.other WOS: 000386772100010
dc.identifier.other Scopus: 84983417841
dc.identifier.uri http://hdl.handle.net/10138/169572
dc.description.abstract OBJECTIVES: Oxidative stress (OS) is an essential element in the pathogenesis of Barrett's esophagus (BE) and its transformation to adenocarcinoma (EAC). The state of OS in the proximal stomach of patients with BE and EAC is unknown. Isoprostanes are a specific marker of OS not previously used to determine OS from BE/EAC tissue samples. PATIENTS AND METHODS: OS was measured in 42 patients with BE (n = 9), EAC (n = 9), or both (n = 24) and 15 control patients. A STAT-8-Isoprostane EIA Kit served to identify 8-Isoprostanes (8-IP), and a Glutathione Assay Kit was used to measure glutathione reduced form(GSH) and glutathione oxidized form. An OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG) served to measure 8-OH-deoxyguanosine. RESULTS: The 8-IP (P = .039) and 8-OHdG (P = .008) levels were higher, and the GSH level lower (P = .031), in the proximal stomach of the study group than in that of the controls. Helicobacter pylori infection was present in 8% of the study patients. CONCLUSIONS: In the proximal stomach of BE and EAC patients, OS was elevated and antioxidative capacity was reduced. This finding suggests that the gastroesophageal reflux causing BE also induces oxidative stress in the proximal stomach and may contribute to the development of cancer in the proximal stomach and gastric cardia. en
dc.format.extent 4
dc.language.iso eng
dc.relation.ispartof Translational oncology
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject HELICOBACTER-PYLORI INFECTION
dc.subject GASTROESOPHAGEAL-REFLUX
dc.subject FREE-RADICALS
dc.subject GASTRIC CARDIA
dc.subject DNA-ADDUCTS
dc.subject CANCER
dc.subject GLUTATHIONE
dc.subject CARCINOGENESIS
dc.subject INFLAMMATION
dc.subject EXPRESSION
dc.subject 3122 Cancers
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Increased Oxidative Stress in the Proximal Stomach of Patients with Barrett's Esophagus and Adenocarcinoma of the Esophagus and Esophagogastric Junction en
dc.type Article
dc.contributor.organization III kirurgian klinikka
dc.contributor.organization Clinicum
dc.contributor.organization Department of Surgery
dc.contributor.organization Gastroenterologian yksikkö
dc.contributor.organization Department of Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.tranon.2016.06.004
dc.relation.issn 1936-5233
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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