Magnetic Resonance Imaging as a Predictor of Survival Free of Life-Threatening Arrhythmias and Transplantation in Cardiac Sarcoidosis

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Ekstrom , K , Lehtonen , J , Hänninen , H , Kandolin , R , Kivistö , S & Kupari , M 2016 , ' Magnetic Resonance Imaging as a Predictor of Survival Free of Life-Threatening Arrhythmias and Transplantation in Cardiac Sarcoidosis ' , Journal of the American Heart Association , vol. 5 , no. 5 , 003040 . https://doi.org/10.1161/JAHA.115.003040

Title: Magnetic Resonance Imaging as a Predictor of Survival Free of Life-Threatening Arrhythmias and Transplantation in Cardiac Sarcoidosis
Author: Ekstrom, Kaj; Lehtonen, Jukka; Hänninen, Helena; Kandolin, Riina; Kivistö, Sari; Kupari, Markku
Contributor: University of Helsinki, Kimmo Kontula / Principal Investigator
University of Helsinki, Department of Medicine
University of Helsinki, Kardiologian yksikkö
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Clinicum
Date: 2016-05
Language: eng
Number of pages: 12
Belongs to series: Journal of the American Heart Association
ISSN: 2047-9980
URI: http://hdl.handle.net/10138/169580
Abstract: Background-Cardiac magnetic resonance imaging has a key role in today's diagnosis of cardiac sarcoidosis. We set out to investigate whether cardiac magnetic resonance imaging also helps predict outcome in cardiac sarcoidosis. Methods and Results-Our work involved 59 patients with cardiac sarcoidosis (38 female, mean age 46 +/- 10 years) seen at our hospital since February 2004 and followed up after contrast-enhanced cardiac magnetic resonance imaging. The extent of myocardial late gadolinium enhancement (measured as percentage of left ventricular mass), the volumes and ejection fractions of the left and right ventricles, and the thickness of the basal interventricular septum were determined and analyzed for prognostic significance. By April 2015, 23 patients had reached the study's end point, consisting of a composite of cardiac death (n=3), cardiac transplantation (n=1), and occurrence of life-threatening ventricular tachyarrhythmias (n=19; ventricular fibrillation in 5 and sustained ventricular tachycardia in 14 patients). In univariate analysis, myocardial extent of late gadolinium enhancement predicted event-free survival, as did scar-like thinning (22% (third tertile) had positive and negative predictive values for serious cardiac events of 75% and 76%, respectively. Conclusions-Findings on cardiac magnetic resonance imaging and the extent of myocardial late gadolinium enhancement in particular help predict serious cardiac events in cardiac sarcoidosis.
Subject: implanted cardioverter defibrillator
magnetic resonance imaging
sarcoidosis
ventricular tachycardia
LATE GADOLINIUM ENHANCEMENT
GIANT-CELL MYOCARDITIS
DIAGNOSIS
OUTCOMES
THERAPY
EVENTS
DEATH
3121 Internal medicine
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