Long-term survival and late events after allogeneic stem cell transplantation from HLA-matched siblings for acute myeloid leukemia with myeloablative compared to reduced-intensity conditioning : a report on behalf of the acute leukemia working party of European group for blood and marrow transplantation

Show full item record



Permalink

http://hdl.handle.net/10138/169909

Citation

Shimoni , A , Labopin , M , Savani , B , Volin , L , Ehninger , G , Kuball , J , Bunjes , D , Schaap , N , Vigouroux , S , Bacigalupo , A , Veelken , H , Sierra , J , Eder , M , Niederwieser , D , Mohty , M & Nagler , A 2016 , ' Long-term survival and late events after allogeneic stem cell transplantation from HLA-matched siblings for acute myeloid leukemia with myeloablative compared to reduced-intensity conditioning : a report on behalf of the acute leukemia working party of European group for blood and marrow transplantation ' Journal of Hematology & Oncology , vol. 9 , 118 . DOI: 10.1186/s13045-016-0347-1

Title: Long-term survival and late events after allogeneic stem cell transplantation from HLA-matched siblings for acute myeloid leukemia with myeloablative compared to reduced-intensity conditioning : a report on behalf of the acute leukemia working party of European group for blood and marrow transplantation
Author: Shimoni, Avichai; Labopin, Myriam; Savani, Bipin; Volin, Liisa; Ehninger, Gerhard; Kuball, Jurgen; Bunjes, Donald; Schaap, Nicolaas; Vigouroux, Stephane; Bacigalupo, Andrea; Veelken, Hendrik; Sierra, Jorge; Eder, Matthias; Niederwieser, Dietger; Mohty, Mohamad; Nagler, Arnon
Contributor: University of Helsinki, Department of Medicine
Date: 2016-11-08
Language: eng
Number of pages: 10
Belongs to series: Journal of Hematology & Oncology
ISSN: 1756-8722
URI: http://hdl.handle.net/10138/169909
Abstract: Background: Myeloablative (MAC) and reduced-intensity conditioning (RIC) are established approaches for allogeneic stem cell transplantation (SCT) in acute myeloid leukemia (AML). Most deaths after MAC occur within the first 2 years after SCT, while patients surviving leukemia-free for 2 years can expect a favorable long-term outcome. However, there is paucity of data on the long-term outcome (beyond 10 years) and the pattern of late events following RIC due to the relative recent introduction of this approach. Methods: We analyzed long-term outcomes in a cohort of 1423 AML patients, age >= 50 years, after SCT from HLA-matched siblings, during the years 1997-2005, median follow-up 8.3 years (0.1-17). Results: The 10-year leukemia-free survival (LFS) was 31 % (95CI, 27-35) and 32 % (28-35) after MAC and RIC, respectively (P = 0.57). The 10-year GVHD/relapse-free survival (GRFS), a surrogate for quality of life was 22 % (18-25) and 21 % (18-24), respectively (P = 0.79). The 10-year non-relapse mortality (NRM) was higher and relapse rate was lower after MAC, throughout the early and late post-transplant course. The 10-year LFS among 584 patients surviving leukemia-free 2 years after SCT was 71 % (65-76) and 73 % (67-78) after MAC and RIC, respectively (P = 0.76). Advanced leukemia at SCT was the major predictor of LFS subsequent to the 2-year landmark. Relapse was the major cause of late death after both regimens; however, NRM and in particular chronic graft-versus-host disease and second cancers were more common causes of late death after MAC. Conclusions: Long-term LFS and GRFS are similar after RIC and MAC. Most events after RIC or MAC occur within the first 2 years after SCT. Patients who are leukemia-free 2 years after SCT can expect similar good subsequent outcome after both approaches.
Subject: Acute myeloid leukemia
Allogeneic stem cell transplantation
Myeloablative conditioning
Reduced-intensity conditioning
Long-term outcome
PREPARATIVE REGIMENS
DOSE INTENSITY
PHASE-3 TRIAL
LATE DEATHS
OPEN-LABEL
AML
REMISSION
EBMT
MDS
MORTALITY
3122 Cancers
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
art_3A10.1186_2Fs13045_016_0347_1.pdf 635.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record