Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction

Show full item record



Permalink

http://hdl.handle.net/10138/170071

Citation

Soderholm , S , Fu , Y , Gaelings , L , Belanov , S , Yetukuri , L , Berlinkov , M , Cheltsov , A V , Anders , S , Aittokallio , T , Nyman , T A , Matikainen , S & Kainov , D E 2016 , ' Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction ' , Viruses-Basel , vol. 8 , no. 10 , 269 . https://doi.org/10.3390/v8100269

Title: Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction
Author: Soderholm, Sandra; Fu, Yu; Gaelings, Lana; Belanov, Sergey; Yetukuri, Laxma; Berlinkov, Mikhail; Cheltsov, Anton V.; Anders, Simon; Aittokallio, Tero; Nyman, Tuula A.; Matikainen, Sampsa; Kainov, Denis E.
Contributor organization: Institute of Biotechnology
Institute for Molecular Medicine Finland
Tero Aittokallio / Principal Investigator
Clinicum
Department of Medicine
Reumatologian yksikkö
Denis Kainov / Principal Investigator
Bioinformatics
Date: 2016-10
Language: eng
Number of pages: 15
Belongs to series: Viruses-Basel
ISSN: 1999-4915
DOI: https://doi.org/10.3390/v8100269
URI: http://hdl.handle.net/10138/170071
Abstract: Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics.
Subject: influenza virus
antiviral agent
proteomics
phosphoproteomics
metabolomics
transcriptomics
genomics
virtual ligand screening
LUNG EPITHELIAL-CELLS
CLATHRIN-MEDIATED ENDOCYTOSIS
IN-VITRO
IMMUNE-RESPONSE
H1N1 INFLUENZA
INFECTED MICE
MDCK CELLS
ORNITHINE TRANSCARBAMYLASE
ANTIINFLUENZA ACTIVITIES
ANTIVIRAL ACTIVITY
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
viruses_08_00269_v2.pdf 3.787Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record