Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction

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http://hdl.handle.net/10138/170071

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Soderholm , S , Fu , Y , Gaelings , L , Belanov , S , Yetukuri , L , Berlinkov , M , Cheltsov , A V , Anders , S , Aittokallio , T , Nyman , T A , Matikainen , S & Kainov , D E 2016 , ' Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction ' , Viruses , vol. 8 , no. 10 , 269 . https://doi.org/10.3390/v8100269

Title: Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction
Author: Soderholm, Sandra; Fu, Yu; Gaelings, Lana; Belanov, Sergey; Yetukuri, Laxma; Berlinkov, Mikhail; Cheltsov, Anton V.; Anders, Simon; Aittokallio, Tero; Nyman, Tuula A.; Matikainen, Sampsa; Kainov, Denis E.
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2016-10
Number of pages: 15
Belongs to series: Viruses
ISSN: 1999-4915
URI: http://hdl.handle.net/10138/170071
Abstract: Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics.
Subject: influenza virus
antiviral agent
proteomics
phosphoproteomics
metabolomics
transcriptomics
genomics
virtual ligand screening
LUNG EPITHELIAL-CELLS
CLATHRIN-MEDIATED ENDOCYTOSIS
IN-VITRO
IMMUNE-RESPONSE
H1N1 INFLUENZA
INFECTED MICE
MDCK CELLS
ORNITHINE TRANSCARBAMYLASE
ANTIINFLUENZA ACTIVITIES
ANTIVIRAL ACTIVITY
3111 Biomedicine
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