Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction

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dc.contributor University of Helsinki, Institute of Biotechnology en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor.author Soderholm, Sandra
dc.contributor.author Fu, Yu
dc.contributor.author Gaelings, Lana
dc.contributor.author Belanov, Sergey
dc.contributor.author Yetukuri, Laxma
dc.contributor.author Berlinkov, Mikhail
dc.contributor.author Cheltsov, Anton V.
dc.contributor.author Anders, Simon
dc.contributor.author Aittokallio, Tero
dc.contributor.author Nyman, Tuula A.
dc.contributor.author Matikainen, Sampsa
dc.contributor.author Kainov, Denis E.
dc.date.accessioned 2016-12-08T08:28:03Z
dc.date.available 2016-12-08T08:28:03Z
dc.date.issued 2016-10
dc.identifier.citation Soderholm , S , Fu , Y , Gaelings , L , Belanov , S , Yetukuri , L , Berlinkov , M , Cheltsov , A V , Anders , S , Aittokallio , T , Nyman , T A , Matikainen , S & Kainov , D E 2016 , ' Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction ' , Viruses , vol. 8 , no. 10 , 269 . https://doi.org/10.3390/v8100269 en
dc.identifier.issn 1999-4915
dc.identifier.other PURE: 72612063
dc.identifier.other PURE UUID: 7ef6ccca-548d-42ab-9ca4-0f1dd43de469
dc.identifier.other WOS: 000387482200008
dc.identifier.other Scopus: 84991248655
dc.identifier.other ORCID: /0000-0002-0886-9769/work/41148407
dc.identifier.other ORCID: /0000-0003-2520-2189/work/40903852
dc.identifier.uri http://hdl.handle.net/10138/170071
dc.description.abstract Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics. en
dc.format.extent 15
dc.language.iso eng
dc.relation.ispartof Viruses
dc.rights en
dc.subject influenza virus en
dc.subject antiviral agent en
dc.subject proteomics en
dc.subject phosphoproteomics en
dc.subject metabolomics en
dc.subject transcriptomics en
dc.subject genomics en
dc.subject virtual ligand screening en
dc.subject LUNG EPITHELIAL-CELLS en
dc.subject CLATHRIN-MEDIATED ENDOCYTOSIS en
dc.subject IN-VITRO en
dc.subject IMMUNE-RESPONSE en
dc.subject H1N1 INFLUENZA en
dc.subject INFECTED MICE en
dc.subject MDCK CELLS en
dc.subject ORNITHINE TRANSCARBAMYLASE en
dc.subject ANTIINFLUENZA ACTIVITIES en
dc.subject ANTIVIRAL ACTIVITY en
dc.subject 3111 Biomedicine en
dc.title Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction en
dc.type Review Article
dc.identifier.doi https://doi.org/10.3390/v8100269
dc.type.uri info:eu-repo/semantics/other
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