First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia : a case control study

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Keikkala , E , Koskinen , S , Vuorela , P , Laivuori , H , Romppanen , J , Heinonen , S & Stenman , U-H 2016 , ' First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia : a case control study ' , BMC Pregnancy and Childbirth , vol. 16 , 378 . https://doi.org/10.1186/s12884-016-1169-4

Title: First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia : a case control study
Author: Keikkala, Elina; Koskinen, Sini; Vuorela, Piia; Laivuori, Hannele; Romppanen, Jarkko; Heinonen, Seppo; Stenman, Ulf-Hakan
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2016-11-25
Language: eng
Number of pages: 10
Belongs to series: BMC Pregnancy and Childbirth
ISSN: 1471-2393
URI: http://hdl.handle.net/10138/170407
Abstract: Background: To study whether maternal serum hyperglycosylated human chorionic gonadotropin (hCG-h) improves first trimester prediction of pre-eclampsia when combined with placental growth factor (PlGF), pregnancy-associated plasma protein-A (PAPP-A) and maternal risk factors. Methods: Gestational-age-adjusted concentrations of hCG, hCG-h, PlGF and PAPP-A were analysed in serum samples by time-resolved immunofluorometric assays at 8-13 weeks of gestation. The case-control study included 98 women who developed pre-eclampsia, 25 who developed gestational hypertension, 41 normotensive women with small-for-gestational-age (SGA) infants and 177 controls. Results: Of 98 women with pre-eclampsia, 24 women developed preterm pre-eclampsia (diagnosis <37 weeks of gestation) and 13 of them had early-onset pre-eclampsia (diagnosis <34 weeks of gestation). They had lower concentrations of PlGF, PAPP-A and proportion of hCG-h to hCG (% hCG-h) than controls. In receiver-operating characteristics (ROC) curve analysis, the area under the curve (AUC) for the combination of PlGF, PAPP-A, % hCG-h, nulliparity and mean arterial blood pressure was 0.805 (95% confidence interval, CI, 0.699-0.912) for preterm pre-eclampsia and 0.870 (95% CI 0.750-0.988) for early-onset pre-eclampsia. Without % hCG-h the AUC values were 0.756 (95% CI 0.651-0.861) and 0.810 (95% CI 0.682-0.938) respectively. For prediction of gestational hypertension, the AUC for % hCG-h was 0.708 (95% CI 0.608-0.808), but for other markers the AUC values were not significant. None of the AUC values were significant for the prediction of SGA infants in normotensive women. Conclusions: First trimester maternal serum % hCG-h tended to improve prediction of preterm and early-onset pre-eclampsia when combined with PlGF, PAPP-A and maternal risk factors.
Subject: Pre-eclampsia
Small-for-gestational-age
Gestational hypertension
Placental growth factor
Hyperglycosylated human chorionic gonadotropin
Pregnancy-associated plasma protein-A
FOR-GESTATIONAL-AGE
EARLY-ONSET PREECLAMPSIA
POPULATION-BASED COHORT
PLASMA-PROTEIN-A
LOW-DOSE ASPIRIN
MATERNAL SERUM
ANGIOGENIC FACTORS
TROPHOBLAST INVASION
1ST-TRIMESTER PREDICTION
TYROSINE KINASE-1
3123 Gynaecology and paediatrics
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