TUHAT-artikkelit: Recent submissions

Now showing items 1-20 of 40199
  • Kokkonen, Tom; Xie, Yuning; Paasonen, Pauli; Gani, Shahzad; Jiang, Lin; Wang, Bo; Zhou, Derong; Qin, Wei; Nie, Wei; Kerminen, Veli-Matti; Petäjä, Tuukka; Sun, Jianning; Kulmala, Markku; Ding, Aijun (2021)
  • Ojala, Hanna; Pietilä, Ilkka (Emerald Group Publishing Limited, 2021)
  • Saarinen, Aino; Harjunen, Ville; Jasinskaja-Lahti, Inga; Jääskeläinen, Iiro P.; Ravaja, Niklas (2021)
    Social touch is increasingly utilized in a variety of psychological interventions, ranging from parent-child interventions to psychotherapeutic treatments. Less attention has been paid, however, to findings that exposure to social touch may not necessarily evoke positive or pleasant responses. Social touch can convey different emotions from love and gratitude to harassment and envy, and persons' preferences to touch and be touched do not necessarily match with each other. This review of altogether 99 original studies focuses on how contextual factors modify target person's behavioral and brain responses to social touch. The review shows that experience of social touch is strongly modified by a variety of toucher-related and situational factors: for example, toucher's facial expressions, physical attractiveness, relationship status, group membership, and touched person's psychological distress. At the neural level, contextual factors modify processing of social touch from early perceptual processing to reflective cognitive evaluation. Based on the review, we present implications for using social touch in behavioral and neuroscientific research designs.
  • Borges, Alvaro H.; O'Connor, Jemma L.; Phillips, Andrew N.; Baker, Jason V.; Vjecha, Michael J.; Losso, Marcelo H.; Klinker, Hartwig; Lopardo, Gustavo; Williams, Ian; Lundgren, Jens D.; INSIGHT SMART Study Grp; ESPRIT Study Grp; SILCAAT Sci Comm; Ristola, Matti A (2014)
  • Onninen, Jani; Pankka, Pekka (2021)
    We show that, for each 1 S-3 in the Sobolev class W-1,W-p(S-3, S-3).
  • Lamminen, Marjukka (2021)
    Microalgae are a diverse group of microorganisms that are an interesting alternative feed resource for ruminant production. Microalgae species with high protein concentration and adequate amino acid (AA) composition can be used to substitute conventional protein feeds, whereas species with high carbohydrate or lipid concentration can be used to supply energy. Microalgal polyunsaturated acids and short-chain fatty acids have potential to improve the nutritive value of ruminant milk and meat for human consumption and mitigate enteric methane emissions. Microalgae composition is very plastid in comparison to conventional ruminant feeds and it can be influenced relatively easily by environmental conditions, such as nutrient supply. Microalgae also contain many compounds, especially carbohydrates and cell coverings, which are not usually found in ruminant feeds. Standard feed evaluation methods involving the use of crucibles or nylon bags (detergent fibre method, in vitro digestibility and in vivo rumen incubation) suit poorly to the analysis of microalgae with microscopic particle size. This paper attempts to give a general overview of the nutritive value (protein, lipids and carbohydrates) of microalgae for ruminant feeding applications and the possibilities to tailor microalgae composition for a certain ruminant feeding objectives. In addition, the key knowledge gaps related to the nutritive value of microalgae for ruminant nutrition are identified.
  • Aubert, Olivier; Yoo, Daniel; Zielinski, Dina; Cozzi, Emanuele; Cardillo, Massimo; Dürr, Michael; Domínguez-Gil, Beatriz; Coll, Elisabeth; Da Silva, Margarida Ivo; Sallinen, Ville; Lemström, Karl; Midtvedt, Karsten; Ulloa, Camilo; Immer, Franz; Weissenbacher, Annemarie; Vallant, Natalie; Basic-Jukic, Nikolina; Tanabe, Kazunari; Papatheodoridis, Georgios; Menoudakou, Georgia; Torres, Martin; Soratti, Carlos; Hansen Krogh, Daniela; Lefaucheur, Carmen; Ferreira, Gustavo; Silva, Helio Tedesco; Hartell, David; Forsythe, John; Mumford, Lisa; Reese, Peter P.; Kerbaul, François; Jacquelinet, Christian; Vogelaar, Serge; Papalois, Vassilios; Loupy, Alexandre (2021)
    Background: Preliminary data suggest that COVID-19 has reduced access to solid organ transplantation. However, the global consequences of the COVID-19 pandemic on transplantation rates and the effect on waitlisted patients have not been reported. We aimed to assess the effect of the COVID-19 pandemic on transplantation and investigate if the pandemic was associated with heterogeneous adaptation in terms of organ transplantation, with ensuing consequences for waitlisted patients. Methods: In this population-based, observational, before-and-after study, we collected and validated nationwide cohorts of consecutive kidney, liver, lung, and heart transplants from 22 countries. Data were collected from Jan 1 to Dec 31, 2020, along with data from the same period in 2019. The analysis was done from the onset of the 100th cumulative COVID-19 case through to Dec 31, 2020. We assessed the effect of the pandemic on the worldwide organ transplantation rate and the disparity in transplant numbers within each country. We estimated the number of waitlisted patient life-years lost due to the negative effects of the pandemic. The study is registered with ClinicalTrials.gov, NCT04416256. Findings: Transplant activity in all countries studied showed an overall decrease during the pandemic. Kidney transplantation was the most affected, followed by lung, liver, and heart. We identified three organ transplant rate patterns, as follows: countries with a sharp decrease in transplantation rate with a low COVID-19-related death rate; countries with a moderate decrease in transplantation rate with a moderate COVID-19-related death rate; and countries with a slight decrease in transplantation rate despite a high COVID-19-related death rate. Temporal trends revealed a marked worldwide reduction in transplant activity during the first 3 months of the pandemic, with losses stabilising after June, 2020, but decreasing again from October to December, 2020. The overall reduction in transplants during the observation time period translated to 48 239 waitlisted patient life-years lost. Interpretation: We quantified the impact of the COVID-19 pandemic on worldwide organ transplantation activity and revealed heterogeneous adaptation in terms of organ transplantation, both at national levels and within countries, with detrimental consequences for waitlisted patients. Understanding how different countries and health-care systems responded to COVID-19-related challenges could facilitate improved pandemic preparedness, notably, how to safely maintain transplant programmes, both with immediate and non-immediate life-saving potential, to prevent loss of patient life-years. Funding: French national research agency (INSERM) ATIP Avenir and Fondation Bettencourt Schueller.
  • Urinboyev, Rustamjon (2020)
    Bokrecension. Recenserat verk: Immigration and Refugee Law in Russia: Socio-Legal Perspectives / By Agnieszka Kubal. - Cambridge : Cambridge University Press, 2019. xxii, 205 s.
  • Framke, Elisabeth; Sørensen, Jeppe Karl; Alexanderson, Kristina; Farrants, Kristin; Kivimäki, Mika; Nyberg, Solja T.; Pedersen, Jacob; Madsen, Ida E.H.; Rugulies, Reiner (2021)
    Background: High emotional demands at work can affect employees’ health and there is a need to understand whether such an association might be modified by other working conditions. We aimed to examine emotional demands at work as a risk factor for long-term sickness absence and analyse whether influence, possibilities for development, role conflicts, and physical demands at work might modify this risk. Methods: We did a nationwide, population-based, prospective cohort study in Denmark and included employed individuals who were residing in Denmark in 2000, aged 30–59 years, who had complete data on age, sex, and migration background, with information on emotional demands and possible effect modifiers from job exposure matrices, and covariates and outcome (sickness absence) from population registers. Individuals with long-term sickness absence (≥6 weeks of consecutive sickness absence) between Jan 1, 1998, and Dec 31, 2000, and self-employed individuals were excluded. We assessed long-term sickness absence during a 10-year period from Jan 1, 2001, to Dec 31, 2010. Using Cox regression, we estimated hazard ratios (HRs) and 95% CIs and tested interaction as departure from additivity, estimating relative excess risk due to interaction (RERI). Multivariable adjusted models included sex, age, cohabitation, migration background, and income. Findings: 1 521 352 employed individuals were included and contributed data between Jan 1, 2000, and Dec 31, 2010. During 11 919 021 person-years (mean follow-up 7·8 years), we identified 480 685 new cases of long-term sickness absence. High emotional demands were associated with increased risk of long-term sickness absence compared with low emotional demands, after adjusting for age, sex, cohabitation, migration background, income, and the four possible effect modifiers (adjusted HR 1·55 [95% CI 1·53–1·56]). The association between high emotional demands and risk of long-term sickness absence was stronger in a synergistic way when individuals were also exposed to low possibilities for development (RERI 0·35 [95% CI 0·22–0·47]; 28·9 additional cases per 1000 person-years) and high role conflicts (0·13 [0·11–0·15]; 22·0 additional cases per 1000 person-years). No synergy was observed for influence and physical demands at work. Interpretation: People in occupations with high emotional demands were at increased risk of long-term sickness absence. Our findings on synergistic interactions suggest that, in emotionally demanding occupations, increasing possibilities for development and reducing work-related role conflicts might reduce long-term sickness absence. Further interventional studies are needed to confirm or refute this hypothesis. Funding: Danish Work Environment Research Fund, NordForsk.
  • Honkanen, Emma A.; Eklund, Mikael; Nuuttila, Simo; Noponen, Tommi; Jaakkola, Elina; Mäkinen, Elina; Hirvilammi, Risto; Seppänen, Marko; Lindholm, Kari; Scheperjans, Filip; Parkkola, Riitta; Joutsa, Juho; Varrone, Andrea; Kaasinen, Valtteri (2021)
    Objective: To evaluate possible differences between brain dopamine transporter (DAT) binding in a group of symptomatic parkinsonism patients without dopaminergic degeneration and healthy individuals. Background: Dopaminergic neuroimaging studies of Parkinson's disease (PD) have often used control groups formed from symptomatic patients with apparently normal striatal dopamine function. We sought to investigate whether symptomatic patients can be used to represent dopaminergically normal healthy controls. Methods: Forty healthy elderly individuals were scanned with DAT [123I]FP-CIT SPECT and compared to 69 age- and sex-matched symptomatic patients with nondegenerative conditions (including essential tremor, drug-induced parkinsonism and vascular parkinsonism). An automated region-of-interest based analysis of the caudate nucleus and the anterior/posterior putamen was performed. Specific binding ratios (SBR = [ROI-occ]/occ) were compared between the groups. Results: DAT binding in symptomatic patients was 8.6% higher in the posterior putamen than in healthy controls (p = 0.03). Binding correlated negatively with age in both groups but not with motor symptom severity, cognitive function or depression ratings. Conclusions: Putaminal DAT binding, as measured with [123I]FP-CIT SPECT, was higher in symptomatic controls than in healthy individuals. The reason for the difference is unclear but can include selection bias when DAT binding is used to aid clinical diagnosis and possible self-selection bias in healthy volunteerism. This effect should be taken into consideration when designing and interpreting neuroimaging trials investigating the dopamine system with [123I]FP-CIT SPECT.
  • Hikmat, Omar; Isohanni, Pirjo; Keshavan, Nandaki; Ferla, Matteo P.; Fassone, Elisa; Abbott, Mary Alice; Bellusci, Marcello; Darin, Niklas; Dimmock, David; Ghezzi, Daniele; Houlden, Henry; Invernizzi, Federica; Kamarus Jaman, Nazreen B.; Kurian, Manju A.; Morava, Eva; Naess, Karin; Ortigoza-Escobar, Juan Darío; Parikh, Sumit; Pennisi, Alessandra; Barcia, Giulia; Tylleskär, Karin B.; Brackman, Damien; Wortmann, Saskia B.; Taylor, Jenny C.; Bindoff, Laurence A.; Fellman, Vineta; Rahman, Shamima (2021)
    Objective: To delineate the full phenotypic spectrum of BCS1L-related disease, provide better understanding of the genotype–phenotype correlations and identify reliable prognostic disease markers. Methods: We performed a retrospective multinational cohort study of previously unpublished patients followed in 15 centres from 10 countries. Patients with confirmed biallelic pathogenic BCS1L variants were considered eligible. Clinical, laboratory, neuroimaging and genetic data were analysed. Patients were stratified into different groups based on the age of disease onset, whether homozygous or compound heterozygous for the c.232A>G (p.Ser78Gly) variant, and those with other pathogenic BCS1L variants. Results: Thirty-three patients were included. We found that growth failure, lactic acidosis, tubulopathy, hepatopathy and early death were more frequent in those with disease onset within the first month of life. In those with onset after 1 month, neurological features including movement disorders and seizures were more frequent. Novel phenotypes, particularly involving movement disorder, were identified in this group. The presence of the c.232A>G (p.Ser78Gly) variant was associated with significantly worse survival and exclusively found in those with disease onset within the first month of life, whilst other pathogenic BCS1L variants were more frequent in those with later symptom onset. Interpretation: The phenotypic spectrum of BCS1L-related disease comprises a continuum of clinical features rather than a set of separate syndromic clinical identities. Age of onset defines BCS1L-related disease clinically and early presentation is associated with poor prognosis. Genotype correlates with phenotype in the presence of the c.232A>G (p.Ser78Gly) variant.
  • Kulkarni, Ritwik; Di Minin, Enrico (2021)
    1. As resources for conservation are limited, gathering and analysing information from digital platforms can help investigate the global biodiversity crisis in a cost-efficient manner. Development and application of methods for automated content analysis of digital data sources are especially important in the context of investigating human-nature interactions. 2. In this study, we introduce novel application methods to automatically collect and analyse textual data on species of conservation concern from digital platforms. An end-to-end pipeline is constructed that begins from searching and downloading news articles about species listed in Appendix I of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) along with news articles from specific Twitter handles and proceeds with implementing natural language processing and machine learning methods to filter and retain only relevant articles. A crucial aspect here is the automatic annotation of training data, which can be challenging in many machine learning applications. A Named Entity Recognition model is then used to extract additional relevant information for each article. 3. The data collected over a 1-month period included 15,088 articles focusing on 585 species listed in Appendix I of CITES. The accuracy of the neural network to detect relevant articles was 95.91% while the Named Entity recognition model helped extract information on prices, location and quantities of traded animals and plants. A regularly updated database, which can be queried and analysed for various research purposes and to inform conservation decision making, is generated by the system. 4. The results demonstrate that natural language processing can be used successfully to extract information from digital text content. The proposed methods can be applied to multiple digital data platforms at the same time and used to investigate human-nature interactions in conservation science and practice.
  • Castelblanco, Esmeralda; Sarrias, Maria R.; Betriu, Angels; Soldevila, Berta; Barranco-Altirriba, Maria; Franch-Nadal, Josep; Valdivielso, Jose M.; Bermudez-Lopez, Marcelino; Groop, Per-Henrik; Fernandez, Elvira; Alonso, Nuria; Mauricio, Didac (2021)
    This study assessed the association of CD5L and soluble CD36 (sCD36) with the risk of a cardiovascular event (CVE), including CV death and all-cause mortality in CKD. We evaluated the association of CD5L and sCD36 with a predefined composite CV endpoint (unstable angina, myocardial infarction, transient ischemic attack, cerebrovascular accident, congestive heart failure, arrhythmia, peripheral arterial disease [PAD] or amputation by PAD, aortic aneurysm, or death from CV causes) and all-cause mortality using Cox proportional hazards regression, adjusted for CV risk factors. The analysis included 1,516 participants free from pre-existing CV disease followed up for 4 years. The median age was 62 years, 38.8% were female, and 26.8% had diabetes. There were 98 (6.5%) CVEs and 72 (4.8%) deaths, of which 26 (36.1%) were of CV origin. Higher baseline CD5L concentration was associated with increased risk of CVE (HR, 95% CI, 1.17, 1.0-1.36), and all-cause mortality (1.22, 1.01-1.48) after adjusting for age, sex, diabetes, systolic blood pressure, dyslipidemia, waist circumference, smoking, and CKD stage. sCD36 showed no association with adverse CV outcomes or mortality. Our study showed for the first time that higher concentrations of CD5L are associated with future CVE and all -cause mortality in individuals with CKD.
  • Salonen, Ari Heimo Kalevi; Salmi, Pauliina; Keskitalo, Jorma (2021)
  • Viitanen, Arto Ilmari; Gullmets, Josef; Morikka, Jack George Anthony; Katajisto, Pekka; Mattila, Jaakko; Hietakangas, Ville (2021)
    The intestine is divided into functionally distinct regions along the anteroposterior (A/P) axis. How the regional identity influences the function of intestinal stem cells (ISCs) and their offspring remain largely unresolved. We introduce an imaging-based method, “Linear Analysis of Midgut” (LAM), which allows quantitative, regionally defined cellular phenotyping of the whole Drosophila midgut. LAM transforms image-derived cellular data from three-dimensional midguts into a linearized representation, binning it into segments along the A/P axis. Through automated multivariate determination of regional borders, LAM allows mapping and comparison of cellular features and frequencies with subregional resolution. Through the use of LAM, we quantify the distributions of ISCs, enteroblasts, and enteroendocrine cells in a steady-state midgut, and reveal unprecedented regional heterogeneity in the ISC response to a Drosophila model of colitis. Altogether, LAM is a powerful tool for organ-wide quantitative analysis of the regional heterogeneity of midgut cells.
  • Candolin, Ulrika; Goncalves, Sara; Pant, Pankaj (2021)
    Recruitment is usually negatively density-dependent with fewer offspring surviving when more are produced. Parental care could alter the pattern as behaviours that maximize individual fitness are not necessarily adaptive at the population level. We manipulated the number of eggs spawned into the nests of male threespine stickleback, and found egg survival to be positively density-dependent. This reversed negative density-dependent survival observed in the absence of parental care. The reversal was caused my males investing more in parental care when receiving more eggs, while favouring future reproductive opportunities when receiving few eggs. Density-dependent parental care thus amplified changes in offspring production in relation to number of eggs spawned. Such amplification may occur in disturbed environments where human activities have altered female fecundity and males may receive more or less eggs than expected. The optimal balancing between present and future parental investment can then be distorted, resulting in maladaptive parental behaviour that reduces offspring survival. These results suggest that behaviours that have evolved to maximize individual fitness under pristine conditions can become mal-adaptive under disturbed conditions and influence the recruitment of offspring into a population. Considering that human activities are rapidly transforming environments, such mal-adaptive behavioural responses could be common and magnify negative effects of human activities on population dynamics.