Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus

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Jager , P , Ye , Z , Yu , X , Zagoraiou , L , Prekop , H-T , Partanen , J , Jessell , T M , Wisden , W , Brickley , S G & Delogu , A 2016 , ' Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus ' , Nature Communications , vol. 7 , 13579 . https://doi.org/10.1038/ncomms13579

Title: Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus
Author: Jager, Polona; Ye, Zhiwen; Yu, Xiao; Zagoraiou, Laskaro; Prekop, Hong-Ting; Partanen, Juha; Jessell, Thomas M.; Wisden, William; Brickley, Stephen G.; Delogu, Alessio
Contributor: University of Helsinki, Biosciences
Date: 2016-12-08
Language: eng
Number of pages: 14
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/172748
Abstract: The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABA(A) receptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability.
Subject: LATERAL GENICULATE-NUCLEUS
GLUTAMIC-ACID DECARBOXYLASE
GABAERGIC INTERNEURONS
GENE-EXPRESSION
RAT THALAMUS
RETINOGENICULATE SYNAPSE
NEURONAL IDENTITY
GABA(A) RECEPTORS
SETTLING PATTERN
RETINAL WAVES
1182 Biochemistry, cell and molecular biology
1184 Genetics, developmental biology, physiology
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