Endotoxins are associated with visceral fat mass in type 1 diabetes

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Lassenius , M I , Ahola , A J , Harjutsalo , V , Forsblom , C , Groop , P-H & Lehto , M 2016 , ' Endotoxins are associated with visceral fat mass in type 1 diabetes ' , Scientific Reports , vol. 6 , 38887 . https://doi.org/10.1038/srep38887

Title: Endotoxins are associated with visceral fat mass in type 1 diabetes
Author: Lassenius, Mariann I.; Ahola, Aila J.; Harjutsalo, Valma; Forsblom, Carol; Groop, Per-Henrik; Lehto, Markku
Contributor organization: Clinicum
Department of Medicine
Nefrologian yksikkö
Research Programs Unit
Diabetes and Obesity Research Program
Per Henrik Groop / Principal Investigator
Date: 2016-12-13
Language: eng
Number of pages: 6
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/srep38887
URI: http://hdl.handle.net/10138/172960
Abstract: Bacterial lipopolysaccharides (LPS), potent inducers of inflammation, have been associated with chronic metabolic disturbances. Obesity is linked to dyslipidemia, increased body adiposity, and endotoxemia. We investigated the cross-sectional relationships between serum LPS activity and body adiposity as well as inflammation in 242 subjects with type 1 diabetes. Body fat distribution was measured by DXA and serum LPS activity by the limulus amebocyte lysate end-point assay. Since no interaction between visceral fat mass and sex was observed, data were pooled for the subsequent analyses. LPS was independently associated with visceral fat mass, when adjusted for traditional risk factors (age, sex, kidney status, hsCRP, insulin sensitivity). In the multivariate analysis, serum LPS activity and triglyceride concentrations had a joint effect on visceral fat mass, independent of these factors alone. A combination of high LPS and high hsCRP concentrations was also observed in those with the largest visceral fat mass. In conclusion, high serum LPS activity levels were associated with visceral fat mass in subjects with type 1 diabetes strengthening its role in the development of central obesity, inflammation and insulin resistance.
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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