Lassenius , M I , Ahola , A J , Harjutsalo , V , Forsblom , C , Groop , P-H & Lehto , M 2016 , ' Endotoxins are associated with visceral fat mass in type 1 diabetes ' , Scientific Reports , vol. 6 , 38887 . https://doi.org/10.1038/srep38887
Title: | Endotoxins are associated with visceral fat mass in type 1 diabetes |
Author: | Lassenius, Mariann I.; Ahola, Aila J.; Harjutsalo, Valma; Forsblom, Carol; Groop, Per-Henrik; Lehto, Markku |
Contributor organization: | Clinicum Department of Medicine Nefrologian yksikkö Research Programs Unit Diabetes and Obesity Research Program Per Henrik Groop / Principal Investigator |
Date: | 2016-12-13 |
Language: | eng |
Number of pages: | 6 |
Belongs to series: | Scientific Reports |
ISSN: | 2045-2322 |
DOI: | https://doi.org/10.1038/srep38887 |
URI: | http://hdl.handle.net/10138/172960 |
Abstract: | Bacterial lipopolysaccharides (LPS), potent inducers of inflammation, have been associated with chronic metabolic disturbances. Obesity is linked to dyslipidemia, increased body adiposity, and endotoxemia. We investigated the cross-sectional relationships between serum LPS activity and body adiposity as well as inflammation in 242 subjects with type 1 diabetes. Body fat distribution was measured by DXA and serum LPS activity by the limulus amebocyte lysate end-point assay. Since no interaction between visceral fat mass and sex was observed, data were pooled for the subsequent analyses. LPS was independently associated with visceral fat mass, when adjusted for traditional risk factors (age, sex, kidney status, hsCRP, insulin sensitivity). In the multivariate analysis, serum LPS activity and triglyceride concentrations had a joint effect on visceral fat mass, independent of these factors alone. A combination of high LPS and high hsCRP concentrations was also observed in those with the largest visceral fat mass. In conclusion, high serum LPS activity levels were associated with visceral fat mass in subjects with type 1 diabetes strengthening its role in the development of central obesity, inflammation and insulin resistance. |
Subject: |
INSULIN-RESISTANCE
INFLAMMATION OBESITY DISEASE SERUM RISK LIPOPOLYSACCHARIDE LIPOPROTEINS ADIPOSITY PROTEIN 3121 General medicine, internal medicine and other clinical medicine |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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