Midlife Physical Activity and Cognition Later in Life : A Prospective Twin Study

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Iso-Markku , P , Waller , K , Vuoksimaa , E , Heikkila , K , Rinne , J , Kaprio , J & Kujala , U M 2016 , ' Midlife Physical Activity and Cognition Later in Life : A Prospective Twin Study ' , Journal of Alzheimer's Disease , vol. 54 , no. 4 , pp. 1303-1317 . https://doi.org/10.3233/JAD-160377

Title: Midlife Physical Activity and Cognition Later in Life : A Prospective Twin Study
Author: Iso-Markku, Paula; Waller, Katja; Vuoksimaa, Eero; Heikkila, Kauko; Rinne, Juha; Kaprio, Jaakko; Kujala, Urho M.
Contributor organization: Clinicum
Department of Diagnostics and Therapeutics
Institute for Molecular Medicine Finland
Department of Public Health
Jaakko Kaprio / Principal Investigator
Genetic Epidemiology
Date: 2016
Language: eng
Number of pages: 15
Belongs to series: Journal of Alzheimer's Disease
ISSN: 1387-2877
DOI: https://doi.org/10.3233/JAD-160377
URI: http://hdl.handle.net/10138/173000
Abstract: Background: Physical activity has been associated with a reduced risk of cognitive decline but the nature of this association remains obscure. Objective: To study associations between midlife physical activity and cognition in old age for a prospective cohort of Finnish twins. Methods: Physical activity in the Finnish Twin Cohort was assessed using questionnaire responses collected in 1975 and 1981. After a mean follow-up of 25.1 years, the subjects' (n = 3050; mean age 74.2; range 66-97) cognition was evaluated with a validated telephone interview. Both participation in vigorous physical activity, and the volume of physical activity, divided into quintiles, were used as predictors of cognitive impairment. Metrics collected by TELE were used to categorize participants as: cognitively impaired, suffering mild cognitive impairment, or cognitively healthy. Results: Participation in vigorous physical activity compared to non-participation for both 1975 and 1981 was associated with a lower risk of cognitive impairment in individual-based analyses (fully adjusted OR 0.50, 95% CI 0.35-0.73). Pairwise analyses yielded similar but statistically non-significant associations. In terms of the volume of physical activity, the most active quintile of individuals (OR 0.69, 95% CI 0.46-1.04) had a reduced risk of cognitive decline compared with the most sedentary quintile in the fully adjusted model although no clear dose-response was found. Conclusion: Vigorous midlife physical activity was associated with less cognitive impairment but without a clear dose-response association between the volume of physical activity and cognition.
Subject: Cohort studies
3112 Neurosciences
3124 Neurology and psychiatry
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion

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