Analysis of nitrogen-based explosives with desorption atmospheric pressure photoionization mass spectrometry

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http://hdl.handle.net/10138/173466

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Kauppila , T J , Flink , A , Pukkila , J & Ketola , R A 2016 , ' Analysis of nitrogen-based explosives with desorption atmospheric pressure photoionization mass spectrometry ' , Rapid Communications in Mass Spectrometry , vol. 30 , no. 4 , pp. 467-475 . https://doi.org/10.1002/rcm.7469

Title: Analysis of nitrogen-based explosives with desorption atmospheric pressure photoionization mass spectrometry
Author: Kauppila, T. J.; Flink, A.; Pukkila, J.; Ketola, R. A.
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Medicum
Date: 2016-02-28
Language: eng
Number of pages: 9
Belongs to series: Rapid Communications in Mass Spectrometry
ISSN: 0951-4198
URI: http://hdl.handle.net/10138/173466
Abstract: RATIONALE: Fast methods that allow the in situ analysis of explosives from a variety of surfaces are needed in crime scene investigations and home-land security. Here, the feasibility of the ambient mass spectrometry technique desorption atmospheric pressure photoionization (DAPPI) in the analysis of the most common nitrogen-based explosives is studied. METHODS: DAPPI and desorption electrospray ionization (DESI) were compared in the direct analysis of trinitrotoluene (TNT), trinitrophenol (picric acid), octogen (HMX), cyclonite (RDX), pentaerythritol tetranitrate (PETN), and nitroglycerin (NG). The effect of different additives in DAPPI dopant and in DESI spray solvent on the ionization efficiency was tested, as well as the suitability of DAPPI to detect explosives from a variety of surfaces. RESULTS: The analytes showed ions only in negative ion mode. With negative DAPPI, TNT and picric acid formed deprotonated molecules with all dopant systems, while RDX, HMX, PETN and NG were ionized by adduct formation. The formation of adducts was enhanced by addition of chloroform, formic acid, acetic acid or nitric acid to the DAPPI dopant. DAPPI was more sensitive than DESI for TNT, while DESI was more sensitive for HMX and picric acid. CONCLUSIONS: DAPPI could become an important method for the direct analysis of nitroaromatics from a variety of surfaces. For compounds that are thermally labile, or that have very low vapor pressure, however, DESI is better suited. Copyright (C) 2016 John Wiley & Sons, Ltd.
Subject: NITRATE ESTER EXPLOSIVES
SOLID-PHASE EXTRACTION
ELECTROSPRAY-IONIZATION
REAL-TIME
LIQUID-CHROMATOGRAPHY
CHEMICAL-IONIZATION
SURFACE SAMPLING/IONIZATION
AMBIENT CONDITIONS
CONFISCATED DRUGS
CURRENT TRENDS
3111 Biomedicine
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