Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke

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Ilves , N , Ilves , P , Laugesaar , R , Juurmaa , J , Mannamaa , M , Loo , S , Loorits , D , Tomberg , T , Kolk , A , Talvik , I & Talvik , T 2016 , ' Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke ' , Neural Plasticity . https://doi.org/10.1155/2016/2306406

Title: Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke
Author: Ilves, Nigul; Ilves, Pilvi; Laugesaar, Rael; Juurmaa, Julius; Mannamaa, Mairi; Loo, Silva; Loorits, Dagmar; Tomberg, Tiiu; Kolk, Anneli; Talvik, Inga; Talvik, Tiina
Contributor: University of Helsinki, Lastenneurologian yksikkö
Date: 2016
Language: eng
Number of pages: 11
Belongs to series: Neural Plasticity
ISSN: 2090-5904
URI: http://hdl.handle.net/10138/173793
Abstract: Perinatal stroke is a leading cause of congenital hemiparesis and neurocognitive deficits in children. Dysfunctions in the largescale resting-state functional networks may underlie cognitive and behavioral disability in these children. We studied resting-state functional connectivity in patients with perinatal stroke collected from the Estonian Pediatric Stroke Database. Neurodevelopment of children was assessed by the Pediatric Stroke Outcome Measurement and the Kaufman Assessment Battery. The study included 36 children (age range 7.6-17.9 years): 10 with periventricular venous infarction (PVI), 7 with arterial ischemic stroke (AIS), and 19 controls. There were no differences in severity of hemiparesis between the PVI and AIS groups. A significant increase in default mode network connectivity (FDR 0.1) and lower cognitive functions (p <0.05) were found in children with AIS compared to the controls and the PVI group. The children with PVI had no significant differences in the resting-state networks compared to the controls and their cognitive functions were normal. Our findings demonstrate impairment in cognitive functions and neural network profile in hemiparetic children with AIS compared to children with PVI and controls. Changes in the resting-state networks found in children with AIS could possibly serve as the underlying derangements of cognitive brain functions in these children.
Subject: ARTERIAL ISCHEMIC-STROKE
INDEPENDENT COMPONENT ANALYSIS
CONGENITAL HEMIPARESIS
CEREBRAL-PALSY
BRAIN IMAGES
RISK-FACTORS
CHILDHOOD
OUTCOMES
INFANTS
REGISTRATION
3123 Gynaecology and paediatrics
3112 Neurosciences
3124 Neurology and psychiatry
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