Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention : The Finnish Gestational Diabetes Prevention Study (RADIEL) A Randomized Controlled Trial

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Koivusalo , S B , Rönö , K , Klemetti , M M , Roine , R P , Lindstrom , J , Erkkola , M , Kaaja , R J , Pöyhönen-Alho , M , Tiitinen , A , Huvinen , E , Andersson , S , Laivuori , H , Valkama , A J , Meinila , J , Kautiainen , H , Eriksson , J G & Stach-Lempinen , B 2016 , ' Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention : The Finnish Gestational Diabetes Prevention Study (RADIEL) A Randomized Controlled Trial ' , Diabetes Care , vol. 39 , no. 1 , pp. 24-30 . https://doi.org/10.2337/dc15-0511

Title: Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention : The Finnish Gestational Diabetes Prevention Study (RADIEL) A Randomized Controlled Trial
Author: Koivusalo, Saila B.; Rönö, Kristiina; Klemetti, Miira M.; Roine, Risto P.; Lindstrom, Jaana; Erkkola, Maijaliisa; Kaaja, Risto J.; Pöyhönen-Alho, Maritta; Tiitinen, Aila; Huvinen, Emilia; Andersson, Sture; Laivuori, Hannele; Valkama, Anita Johanna; Meinila, Jelena; Kautiainen, Hannu; Eriksson, Johan G.; Stach-Lempinen, Beata
Contributor organization: Department of Obstetrics and Gynecology
Clinicum
Department of Food and Nutrition
Maijaliisa Erkkola / Principal Investigator
Children's Hospital
Institute for Molecular Medicine Finland
Pregnancy and Genes
Department of General Practice and Primary Health Care
Johan Eriksson / Principal Investigator
Department of Medical and Clinical Genetics
Medicum
Nutrition Science
HUS Gynecology and Obstetrics
Teachers' Academy
Family nutrition and wellbeing
Date: 2016-01
Language: eng
Number of pages: 7
Belongs to series: Diabetes Care
ISSN: 0149-5992
DOI: https://doi.org/10.2337/dc15-0511
URI: http://hdl.handle.net/10138/173936
Abstract: OBJECTIVE To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention in pregnant women who are at high risk for the disease. RESEARCH DESIGN AND METHODS Two hundred ninety-three women with a history of GDM and/or a prepregnancy BMI of >= 30 kg/m(2) were enrolled in the study at RESULTS A total of 269 women were included in the analyses. The incidence of GDM was 13.9% in the intervention group and 21.6% in the control group ([95% CI 0.40-0.98%]; P = 0.044, after adjustment for age, prepregnancy BMI, previous GDM status, and the number of weeks of gestation). Gestational weight gain was lower in the intervention group (20.58 kg [95% CI 21.12 to 20.04 kg]; adjusted P = 0.037). Women in the intervention group increased their leisure time physical activity more and improved their dietary quality compared with women in the control group. CONCLUSIONS A moderate individualized lifestyle intervention reduced the incidence of GDM by 39% in high-risk pregnant women. These findings may have major health consequences for both the mother and the child.
Subject: OBESE PREGNANT-WOMEN
INCREASING PREVALENCE
GLUCOSE
OVERWEIGHT
PROGRAM
WEIGHT
COHORT
ADULTS
INDEX
RISK
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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