Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention : The Finnish Gestational Diabetes Prevention Study (RADIEL) A Randomized Controlled Trial

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Koivusalo , S B , Rönö , K , Klemetti , M M , Roine , R P , Lindstrom , J , Erkkola , M , Kaaja , R J , Pöyhönen-Alho , M , Tiitinen , A , Huvinen , E , Andersson , S , Laivuori , H , Valkama , A J , Meinila , J , Kautiainen , H , Eriksson , J G & Stach-Lempinen , B 2016 , ' Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention : The Finnish Gestational Diabetes Prevention Study (RADIEL) A Randomized Controlled Trial ' , Diabetes Care , vol. 39 , no. 1 , pp. 24-30 . https://doi.org/10.2337/dc15-0511

Title: Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention : The Finnish Gestational Diabetes Prevention Study (RADIEL) A Randomized Controlled Trial
Author: Koivusalo, Saila B.; Rönö, Kristiina; Klemetti, Miira M.; Roine, Risto P.; Lindstrom, Jaana; Erkkola, Maijaliisa; Kaaja, Risto J.; Pöyhönen-Alho, Maritta; Tiitinen, Aila; Huvinen, Emilia; Andersson, Sture; Laivuori, Hannele; Valkama, Anita Johanna; Meinila, Jelena; Kautiainen, Hannu; Eriksson, Johan G.; Stach-Lempinen, Beata
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, National Institute for Health and Welfare (THL)
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Clinicum
Date: 2016-01
Language: eng
Number of pages: 7
Belongs to series: Diabetes Care
ISSN: 0149-5992
URI: http://hdl.handle.net/10138/173936
Abstract: OBJECTIVE To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention in pregnant women who are at high risk for the disease. RESEARCH DESIGN AND METHODS Two hundred ninety-three women with a history of GDM and/or a prepregnancy BMI of >= 30 kg/m(2) were enrolled in the study at RESULTS A total of 269 women were included in the analyses. The incidence of GDM was 13.9% in the intervention group and 21.6% in the control group ([95% CI 0.40-0.98%]; P = 0.044, after adjustment for age, prepregnancy BMI, previous GDM status, and the number of weeks of gestation). Gestational weight gain was lower in the intervention group (20.58 kg [95% CI 21.12 to 20.04 kg]; adjusted P = 0.037). Women in the intervention group increased their leisure time physical activity more and improved their dietary quality compared with women in the control group. CONCLUSIONS A moderate individualized lifestyle intervention reduced the incidence of GDM by 39% in high-risk pregnant women. These findings may have major health consequences for both the mother and the child.
Subject: OBESE PREGNANT-WOMEN
INCREASING PREVALENCE
GLUCOSE
OVERWEIGHT
PROGRAM
WEIGHT
COHORT
ADULTS
INDEX
RISK
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
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