Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP)

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dc.contributor.author Nordgren, Heli
dc.contributor.author Aaltonen, Kirsi
dc.contributor.author Raunio-Saarnisto, Mirja
dc.contributor.author Sukura, Antti
dc.contributor.author Vapalahti, Olli
dc.contributor.author Sironen, Tarja
dc.date.accessioned 2017-02-02T14:29:02Z
dc.date.available 2017-02-02T14:29:02Z
dc.date.issued 2016-12
dc.identifier.citation Nordgren , H , Aaltonen , K , Raunio-Saarnisto , M , Sukura , A , Vapalahti , O & Sironen , T 2016 , ' Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) ' , PLoS One , vol. 11 , no. 12 , 0168129 , pp. 1-13 . https://doi.org/10.1371/journal.pone.0168129
dc.identifier.other PURE: 79344923
dc.identifier.other PURE UUID: 3b875726-0fe3-49df-8755-c1f8b3e148f7
dc.identifier.other Bibtex: urn:fb7ff00a2b390255348fadb187d86147
dc.identifier.other Scopus: 85006165327
dc.identifier.other WOS: 000392754300058
dc.identifier.other ORCID: /0000-0002-2344-2755/work/43226607
dc.identifier.other ORCID: /0000-0003-2270-6824/work/30029294
dc.identifier.other ORCID: /0000-0001-8901-6866/work/30030547
dc.identifier.other ORCID: /0000-0002-8992-1695/work/75942738
dc.identifier.uri http://hdl.handle.net/10138/174570
dc.description.abstract Fur Animal Epidemic Necrotic Pyoderma (FENP) is a severe, often lethal infectious disease affecting all three fur animal species: mink (Neovision vision), foxes (Vulpes lagopus) and finnraccoons (Nyctereutes procyonoides). Previous studies showed an association between Arcanobacterium phocae and FENP. An experimental infection was conducted to confirm the ability of A. phocae to infect mink either alone or concurrently with a novel Streptococcus sp. found together with A. phocae in many cases of FENP. Different inoculation methods were tested to study possible routes of transmission. Typical signs, and gross- and histopathological findings for FENP were detected when naïve mink were infected with the tissue extract of mink with FENP, using a subcutaneous/ intradermal infection route. Edema, hemorrhage, necrosis and pus formation were detected in the infection site. A pure culture preparation of A. phocae alone or concurrently with the novel Streptococcus sp. caused severe acute signs of lethargy, apathy and anorexia and even mortality. The histopathological findings were similar to those found in naturally occurring cases of FENP. In contrast, the perorally infected mink presented no clinical signs nor any gross- or histopathological lesions. This study showed that A. phocae is able to cause FENP. The study also indicated that predisposing factors such as the environment, the general condition of the animals, temperature and skin trauma contribute to the development of the disease. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof PLoS One
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 413 Veterinary science
dc.title Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP) en
dc.type Article
dc.contributor.organization Veterinary Biosciences
dc.contributor.organization Medicum
dc.contributor.organization Department of Virology
dc.contributor.organization Clinicum
dc.contributor.organization Viral Zoonosis Research Unit
dc.contributor.organization Emerging Infections Research Group
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1371/journal.pone.0168129
dc.relation.issn 1932-6203
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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