A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study

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Haghighi , M , Johnson , S B , Qian , X , Lynch , K F , Vehik , K , Huang , S , TEDDY Study Grp & Knip , M 2016 , ' A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study ' , Scientific Reports , vol. 6 , 30828 . https://doi.org/10.1038/srep30828

Title: A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study
Author: Haghighi, Mona; Johnson, Suzanne Bennett; Qian, Xiaoning; Lynch, Kristian F.; Vehik, Kendra; Huang, Shuai; TEDDY Study Grp; Knip, Mikael
Contributor organization: Clinicum
Mikael Knip / Principal Investigator
Children's Hospital
Lastentautien yksikkö
HUS Children and Adolescents
Date: 2016-08-26
Language: eng
Number of pages: 11
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/srep30828
URI: http://hdl.handle.net/10138/174574
Abstract: Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions.
Description: M. Knip on TEDDY Study Grp -työryhmän jäsen.
Subject: ASSOCIATION ANALYSIS
EPIDEMIOLOGY
STRESS
ONSET
LASSO
TEDDY
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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