Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD

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Petäjä , E , Zhou , Y , Havana , M , Hakkarainen , A , Lundbom , N , Ihalainen , J & Yki-Jarvinen , H 2016 , ' Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD ' , Scientific Reports , vol. 6 , 24740 . https://doi.org/10.1038/srep24740

Title: Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD
Author: Petäjä, Elina; Zhou, You; Havana, Marika; Hakkarainen, Antti; Lundbom, Nina; Ihalainen, Jarkko; Yki-Jarvinen, Hannele
Contributor organization: Clinicum
Department of Medicine
Department of Diagnostics and Therapeutics
Date: 2016-04-19
Language: eng
Number of pages: 8
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/srep24740
URI: http://hdl.handle.net/10138/174953
Abstract: Insulin-like growth factor binding protein 1 (IGFBP-1) is a potentially interesting marker for liver fat in NAFLD as it is exclusively produced by the liver, and insulin is its main regulator. We determined whether measurement of fasting serum phosphorylated IGFBP-1 (fS-pIGFBP-1) helps to predict liver fat compared to routinely available clinical parameters and PNPLA3 genotype at rs738409. Liver fat content (proton magnetic resonance spectroscopy) was measured in 378 subjects (62% women, age 43 [30-54] years, BMI 32.7 [28.1-39.7] kg/m(2), 46% with NAFLD). Subjects were randomized to discovery and validation groups, which were matched for clinical and biochemical parameters and PNPLA3 genotype. Multiple linear regression and Random Forest modeling were used to identify predictors of liver fat. The final model, % Liver Fat Equation', included age, fS-pIGFBP-1, S-ALT, waist-to-hip ratio, fP-Glucose and fS-Insulin (adjusted R-2 = 0.44 in the discovery group, 0.49 in the validation group, 0.47 in all subjects). The model was significantly better than a model without fS-pIGFBP-1 or S-ALT or S-AST alone. Random Forest modeling identified fS-p-IGFBP-1 as one of the top five predictors of liver fat (adjusted R-2 = 0.39). Therefore, measurement of fS-pIGFBP-1 may help in non-invasive prediction of liver fat content.
Subject: FACTOR-BINDING PROTEIN-1
HEPATIC INSULIN SENSITIVITY
GENERAL-POPULATION
IN-VIVO
IGF-I
STEATOSIS
DISEASE
RESISTANCE
DIAGNOSIS
PLASMA
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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