Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection

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Laine , O , Joutsi-Korhonen , L , Lassila , R , Huhtala , H , Vaheri , A , Makela , S & Mustonen , J 2016 , ' Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection ' , Medicine (Baltimore) , vol. 95 , no. 52 , 5689 . https://doi.org/10.1097/MD.0000000000005689

Title: Elevated thrombopoietin and platelet indices confirm active thrombopoiesis but fail to predict clinical severity of puumala hantavirus infection
Author: Laine, Outi; Joutsi-Korhonen, Lotta; Lassila, Riitta; Huhtala, Heini; Vaheri, Antti; Makela, Satu; Mustonen, Jukka
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Virology



Date: 2016-12
Language: eng
Number of pages: 6
Belongs to series: Medicine (Baltimore)
ISSN: 0025-7974
DOI: https://doi.org/10.1097/MD.0000000000005689
URI: http://hdl.handle.net/10138/174960
Abstract: We evaluated the mechanisms of thrombocytopenia and procoagulant changes in relation with clinical variables in a cohort of patients with acute hantavirus disease. Blood samples of 33 prospectively recruited, consecutive, hospitalized patients with acute Puumala virus-induced hemorrhagic fever with renal syndrome (HFRS) were collected acutely and at the recovery visit (control). Serum thrombopoietin (TPO) and activity of plasma microparticles (MPs) from various cell sources were measured with enzyme-linked immunosorbent assay-based methods. The results were related to data on platelet indices and functions, coagulation variables, and clinical disease. Serum TPO was nearly 4-fold higher acutely compared with the control (median 207pg/mL, range 56-1258pg/mL vs. median 58 pg/mL, range 11-241pg/mL, P Upregulated TPO together with high MPV and IPF% confirm active thrombopoiesis, but do not predict severity of HFRS. Simultaneously, elevated prothrombin fragments and D-dimer suggest increased consumption of platelets in patients with severe AKI. Activity of platelet-derived MPs in HFRS should be studied with flow cytometry in a larger cohort of patients.
Subject: coagulation
hantavirus
kidney
microparticle
platelet
platelet indices
thrombopoietin
CIRCULATING MICROPARTICLES
THROMBOCYTOPENIA
STANDARDIZATION
COMMUNICATION
MICROVESICLES
AGGREGATION
ACTIVATION
EXPRESSION
THROMBOSIS
DISEASE
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
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